維生素缺乏飼料 – 協(xié)同生物 http://www.ychljhotel.com/en 26年專注實(shí)驗(yàn)動物飼料研發(fā)及生產(chǎn) Wed, 19 Jul 2023 02:20:39 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.12 http://www.ychljhotel.com/en/wp-content/uploads/2021/06/cropped-Logo-2-32x32.png 維生素缺乏飼料 – 協(xié)同生物 http://www.ychljhotel.com/en 32 32 維生素D缺乏飼料引起小鼠高血壓并加速動脈粥樣硬化 http://www.ychljhotel.com/en/%e7%bb%b4%e7%94%9f%e7%b4%a0d%e7%bc%ba%e4%b9%8f%e9%a5%b2%e6%96%99%e5%bc%95%e8%b5%b7%e5%b0%8f%e9%bc%a0%e9%ab%98%e8%a1%80%e5%8e%8b%e5%b9%b6%e5%8a%a0%e9%80%9f%e5%8a%a8%e8%84%89%e7%b2%a5%e6%a0%b7%e7%a1%ac/ http://www.ychljhotel.com/en/%e7%bb%b4%e7%94%9f%e7%b4%a0d%e7%bc%ba%e4%b9%8f%e9%a5%b2%e6%96%99%e5%bc%95%e8%b5%b7%e5%b0%8f%e9%bc%a0%e9%ab%98%e8%a1%80%e5%8e%8b%e5%b9%b6%e5%8a%a0%e9%80%9f%e5%8a%a8%e8%84%89%e7%b2%a5%e6%a0%b7%e7%a1%ac/#respond Mon, 22 Mar 2021 06:01:11 +0000 http://www.ychljhotel.com/?p=5379 多種流行病學(xué)研究將維生素D缺乏與心血管疾?。–VD）聯(lián)系起來，但這些聯(lián)系的因果關(guān)系和機(jī)制尚未明確。為了闡明維生素D缺乏在心血管疾病中的作用，我們在兩種背景的小鼠（LDL受體和ApoE缺失小鼠）中建立了飲食誘導(dǎo)維生素D缺乏模型，這兩種小鼠背景類似于飲食性高血壓和動脈粥樣硬化的人類。

誘導(dǎo)過程及結(jié)果評估

給實(shí)驗(yàn)組和對照組小鼠分別喂食維生素D缺乏飼料及充足飼料6周，然后改為高脂肪維生素D缺乏飼料及充足飼料8-10周。飲食誘導(dǎo)的維生素D缺乏小鼠收縮壓和舒張壓升高，血漿腎素升高，尿鈉排泄減少。隨后給維生素D缺乏小鼠重新喂食維生素D充足飼料6周，高血壓得到逆轉(zhuǎn)，腎素得到抑制。

在高脂飲食過程中，與維生素D充足的小鼠相比，維生素D缺乏小鼠的主動脈弓動脈粥樣硬化加快2倍，胸腹主動脈動脈粥樣硬化加快2-8倍。在主動脈根部，高脂飼料喂養(yǎng)的維生素D缺乏小鼠的巨噬細(xì)胞浸潤增加，脂肪積聚和內(nèi)質(zhì)網(wǎng)（ER）應(yīng)激激活增加，但動脈粥樣硬化斑塊內(nèi)M1巨噬細(xì)胞表型的發(fā)生率較低。同樣，維生素D缺乏小鼠腹腔巨噬細(xì)胞表現(xiàn)出M2為主的表型，泡沫細(xì)胞形成和內(nèi)質(zhì)網(wǎng)應(yīng)激增加。高脂飼料喂養(yǎng)期間用內(nèi)質(zhì)網(wǎng)應(yīng)激緩解劑PBA治療維生素D缺乏小鼠可抑制動脈粥樣硬化，減少腹腔巨噬細(xì)胞泡沫細(xì)胞的形成，下調(diào)內(nèi)質(zhì)網(wǎng)應(yīng)激蛋白而不改變血壓。

因此，我們認(rèn)為維生素D缺乏會激活腎素血管緊張素系統(tǒng)和巨噬細(xì)胞內(nèi)質(zhì)網(wǎng)應(yīng)激，從而促進(jìn)高血壓的發(fā)展和加速動脈粥樣硬化，維生素D替代療法是一種潛在的降壓和動脈粥樣硬化治療方法。

原文檢索：Vitamin D Deficiency Induces High Blood Pressure and Accelerates Atherosclerosis in Mice, PLOS ONE

]]> http://www.ychljhotel.com/en/%e7%bb%b4%e7%94%9f%e7%b4%a0d%e7%bc%ba%e4%b9%8f%e9%a5%b2%e6%96%99%e5%bc%95%e8%b5%b7%e5%b0%8f%e9%bc%a0%e9%ab%98%e8%a1%80%e5%8e%8b%e5%b9%b6%e5%8a%a0%e9%80%9f%e5%8a%a8%e8%84%89%e7%b2%a5%e6%a0%b7%e7%a1%ac/feed/ 0 Vitamin Deficiency Model Feed http://www.ychljhotel.com/en/4826/ http://www.ychljhotel.com/en/4826/#respond Fri, 11 Dec 2020 01:00:10 +0000 http://www.ychljhotel.com/?p=4826 Purified feed is a kind of feed made up of highly purified and refined raw materials. The nutrient composition and the source of raw materials are stable, there are many factors affecting the absorption and metabolism of nutrients (e.g. phytic acid, oxalic acid, phytoestrogens, etc.) and contain more than one nutrient, which makes it difficult to modify the feed formula. Especially in the experiment of nutrient deficiency, the diet feed is not feasible, so the purified feed is suggested to be used in constructing the vitamin deficiency model. We can not list all the formulas on our website because of the large number of vitamin-deficient feed formulas. The type of feed available for vitamin-deficient production is shown below.

Product Code：XTVV

Intended species: experimental rat?/?mouse?(C57, ICR, BALB?/?C, SD and other common strains)

Product shape: rod-shaped particles (if there is a special need to provide powder, etc.)

Product storage method: 4 ℃ cold storage?(recommended) or room temperature

Product shelf life: 3?months

Order feed dosage: mice: 5 g /?animal?/?day,?rats: 25 g?/?animal?/?day

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