{"id":4371,"date":"2020-09-16T14:09:18","date_gmt":"2020-09-16T06:09:18","guid":{"rendered":"http:\/\/www.jsxtsw.com\/?p=4371"},"modified":"2020-09-16T14:14:29","modified_gmt":"2020-09-16T06:14:29","slug":"%e5%85%8d%e7%96%ab%e7%bc%ba%e9%99%b7%e5%b0%8f%e9%bc%a0%e7%9a%84%e5%8f%91%e5%b1%95%e5%8f%b2%e5%8f%8a%e5%ba%94%e7%94%a8%e9%a2%86%e5%9f%9f","status":"publish","type":"post","link":"http:\/\/www.jsxtsw.com\/en\/%e5%85%8d%e7%96%ab%e7%bc%ba%e9%99%b7%e5%b0%8f%e9%bc%a0%e7%9a%84%e5%8f%91%e5%b1%95%e5%8f%b2%e5%8f%8a%e5%ba%94%e7%94%a8%e9%a2%86%e5%9f%9f\/","title":{"rendered":"\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7684\u53d1\u5c55\u53f2\u53ca\u5e94\u7528\u9886\u57df"},"content":{"rendered":"

\u514d\u75ab\u7f3a\u9677\u52a8\u7269\u5df2\u7ecf\u6210\u4e3a\u4eba\u7c7b\u7814\u7a76\u80bf\u7624\u514d\u75ab\u6700\u4e3a\u91cd\u8981\u7684\u5de5\u5177\u3002\u901a\u8fc7\u4e86\u89e3\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20<\/a>\u7684\u53d1\u5c55\u5386\u53f2\uff0c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7684\u7279\u70b9\u53ca\u5176\u76f8\u5173\u7814\u7a76\u7684\u57fa\u7840\u77e5\u8bc6\u3002<\/p>\n

\"\"<\/p>\n

\u4e00\u3001\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7684\u53d1\u5c55\u53f2<\/strong><\/p>\n

1. Nude\u5c0f\u9f20\uff0c1966\u5e74<\/span><\/p>\n

\u79d1\u5b66\u5bb6\u9996\u6b21\u53d1\u73b0\u5728C57BL\/6\u54c1\u7cfb\u4e2d\u7684Foxn1\u57fa\u56e0\u7a81\u53d8\u4f1a\u5bfc\u81f4\u80f8\u817a\u4e0a\u76ae\u7ec6\u80de\u53d1\u80b2\u5f02\u5e38\uff0c\u8868\u73b0\u51fa\u6ca1\u6709\u6bdb\u53d1\uff0c\u4e14\u81f4\u4f7f\u8840\u6db2\u4e2d\u7f3a\u4e4fT\u7ec6\u80de\uff0c\u5c0f\u9f20\u514d\u75ab\u529b\u663e\u8457\u964d\u4f4e\uff0c\u4f46NK\u7ec6\u80de\u6d3b\u6027\u589e\u5f3a\uff0c\u4f53\u6db2\u514d\u75ab\u80fd\u529b\u6b63\u5e38\uff0c\u5bfc\u81f4\u4eba\u7c7b\u9020\u8840\u5e72\u7ec6\u80de\u65e0\u6cd5\u79fb\u690d\u3002\u53ef\u7528\u4e8e\u4eba\u7c7b\u80bf\u7624\u53ca\u5404\u79cd\u514d\u75ab\u7f3a\u9677\u75be\u75c5\u7684\u7814\u7a76\u3002<\/p>\n

2. CB17-scid\u5c0f\u9f20\uff0c1983\u5e74<\/span><\/p>\n

1983\u5e74\u79d1\u5b66\u5bb6\u53d1\u73b0\u5728CB17\u5c0f\u9f20\u54c1\u7cfb\u4e2d\u7684Prkdc\u7a81\u53d8\u9996\u6b21\u8ba9\u4eba\u7c7bPBMCs\u80fd\u591f\u5728\u8be5\u5c0f\u9f20\u54c1\u7cfb\u4e2d\u7684\u79fb\u690d\u5f97\u4ee5\u6781\u4f4e\u6c34\u5e73\u7684\u5b58\u6d3b\uff0c\u4f46\u65e0\u6cd5\u91cd\u5efa\u4eba\u7c7b\u514d\u75ab\u7cfb\u7edf\u3002\u540e\u7eed\u7814\u7a76\u53d1\u73b0CB17-Scid\u7f3a\u4e4f\u6210\u719f\u7684T\u7ec6\u80de\u548cB\u7ec6\u80de\uff0c\u4f46\u4f9d\u7136\u5b58\u5728\u5f88\u9ad8\u7684NK\u7ec6\u80de\u6d3b\u6027\u548c\u56fa\u6709\u514d\u75ab\u529b\uff0c\u5bfc\u81f4\u9020\u8840\u4eba\u7c7b\u5e72\u7ec6\u80de\u65e0\u6cd5\u79fb\u690d\uff0c\u8be5\u54c1\u7cfb\u8fd8\u662f\u96be\u4ee5\u6210\u4e3a\u597d\u7684\u4eba\u6e90\u5316\u5c0f\u9f20\u6a21\u578b\u3002<\/p>\n

3\uff0eNod-scid\u5c0f\u9f20\uff0c1995\u5e74<\/span><\/p>\n

\u5076\u7136\u7684\u673a\u4f1aShultz\u53d1\u73b0\u5c06scid\u7a81\u53d8\u5c0f\u9f20\u548cNon-obesediabetic\uff08NOD\uff09\u5c0f\u9f20\u6742\u4ea4\u540e\u51fa\u751f\u7684NOD-scid\u5c0f\u9f20\u80fd\u591f\u652f\u6301\u66f4\u591a\u4eba\u7c7bPBMCs\u6216\u8005\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u751f\u957f\uff0c\u540e\u7eed\u7814\u7a76\u53d1\u73b0\u8be5\u6742\u4ea4\u54c1\u7cfb\u6291\u5236\u4e86NK\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5e76\u4e14\u8fd8\u4f34\u968f\u6709\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u7f3a\u9677\u3002\u8be5\u54c1\u7cfb\u6210\u4e3a\u8fd120\u5e74\u5e94\u7528\u6700\u5e7f\u7684\u91cd\u75c7\u514d\u75ab\u7f3a\u9677\u578b\u5c0f\u9f20\uff0c\u5e76\u4e14\u548c\u4f17\u591a\u4e0d\u540c\u54c1\u7cfb\u6742\u4ea4\u4ea7\u751f\u4e86\u66f4\u591a\u7684\u4e9a\u578b\u5c0f\u9f20\u3002<\/p>\n

4. IL2rg\u5c0f\u9f20\uff0c1995\u5e74<\/span><\/p>\n

1995\u5e74\uff0c\u6570\u4e2a\u72ec\u7acb\u7684\u5b9e\u9a8c\u5ba4\u62a5\u544a\u4e86IL-2R\u03b3-chain\u57fa\u56e0\u4f4d\u70b9\u7684\u7a81\u53d8\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u6dcb\u5df4\u7cfb\u7edf\u53d1\u80b2\u4e0d\u826f\u3002IL-2R\u03b3-chain\u662f\u7ec6\u80de\u56e0\u5b50IL-2\uff0c4\uff0c7\uff0c9\uff0c15\u548c21\u53d7\u4f53\u7684\u81f3\u5173\u91cd\u8981\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u800c\u5176\u7a81\u53d8\u5c06\u5bfc\u81f4\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u7684\u4fe1\u53f7\u4f20\u5bfc\u53d7\u963b\uff0c\u4f7f\u5f97NK\u7ec6\u80de\u53d1\u80b2\u4e25\u91cd\u53d7\u963b\uff0c\u4e14T\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u529f\u80fd\u4e5f\u53d7\u5230\u6781\u5927\u7684\u7834\u574f\u3002\u5728\u540e\u9762\u6570\u5e74\u4e2d\u8fdb\u4e00\u6b65\u5f97\u5230\u4e86IL2rg-\/-\u5c0f\u9f20\uff0c\u5728\u6b64\u5c0f\u9f20\u4e2d\u4eba\u7c7b\u9020\u8840\u5e72\u7ec6\u80de\u548cPBMCs\u7684\u79fb\u690d\u53d8\u5f97\u5bb9\u6613\u4e86\u5f88\u591a\u3002<\/p>\n

5. Rag1-\/-\u548cRag2-\/-\u5c0f\u9f20\uff0c2000\u5e74<\/span><\/p>\n

\u79d1\u5b66\u5bb6\u53d1\u73b0Rag1\u57fa\u56e0\u6572\u9664\u540e\uff0c\u5c0f\u9f20\u4f53\u5185\u7684V(D)J\u91cd\u7ec4\u4e27\u5931\uff0cT\u548cB\u6dcb\u5df4\u7ec6\u80de\u5206\u5316\u3001\u53d1\u80b2\u88ab\u5b8c\u5168\u963b\u65ad\uff0c\u4f7f\u5f97\u5c0f\u9f20\u8840\u6db2\u4e2dT\u7ec6\u80de\u548cB\u7ec6\u80de\u4e27\u5931\u4e86\u6b63\u5e38\u7684\u529f\u80fd\uff0c\u5f15\u8d77\u4e00\u7c7b\u4e25\u91cd\u7684\u8054\u5408\u514d\u75ab\u7f3a\u9677\uff0c\u540c\u6837\u7684\u8868\u578b\u5728Rag2\u7a81\u53d8\u5c0f\u9f20\u4e2d\u4e5f\u53d1\u751f\u4e86\u3002<\/p>\n

\u4e8c\u3001\u5e38\u7528\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7279\u5f81\u5bf9\u6bd4<\/strong><\/p>\n

\"\"<\/p>\n

\u4e09\u3001\u90e8\u5206\u91cd\u8981\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u53ca\u5176\u53d1\u5c55\u65b9\u5411<\/strong><\/p>\n

1. \u5176\u4e2d\u6700\u53d7\u5173\u6ce8\u7684\u4fbf\u662fNRG\u5c0f\u9f20\uff08Rag2\uff0cIL2rg\u53cc\u6572\u5c0f\u9f20\uff09\uff0c\u666e\u904d\u8ba4\u4e3a\u662f\u5f53\u4eca\u514d\u75ab\u7f3a\u9677\u7a0b\u5ea6\u6700\u9ad8\u7684\u52a8\u7269\u6a21\u578b\u3002\u5c06\u53ef\u8bf1\u5bfc\u7684uPA\u7cfb\u7edf\u5f15\u5165\u8be5\u54c1\u7cfb\uff0c\u751f\u4ea7\u51faURG\u5c0f\u9f20\uff0c\u636e\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0cURG\u8db3\u4ee5\u5ab2\u7f8eFRG\u5c0f\u9f20\uff0c\u53ef\u4ee5\u91cd\u5efa\u6700\u9ad880%\u7684\u4eba\u7c7b\u809d\u810f\u7ec4\u7ec7\uff0c\u7528\u6765\u7814\u7a76HBV\u548cHCV\u611f\u67d3\uff0c\u4ee5\u53ca\u836f\u7269\u6bd2\u6027\u548c\u4ee3\u8c22\u8fc7\u7a0b\u3002<\/p>\n

2. NRG\u4e0eFah-\/-\u5c0f\u9f20\u6742\u4ea4\u83b7\u5f97\u7684FRG\u5c0f\u9f20\u6210\u4e3a\u4e86\u4eba\u6e90\u5316\u809d\u810f\u7814\u7a76\u9886\u57df\u6700\u91cd\u8981\u7684\u6a21\u578b\uff0c\u5229\u7528\u8fd9\u4e2a\u6a21\u578b\uff0c\u4f7f\u5f97\u6211\u4eec\u7814\u7a76\u5f97\u4ee5\u7814\u7a76\u809d\u810f\u7ea4\u7ef4\u5316\u75be\u75c5\uff0c\u809d\u810f\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u836f\u7269\u4ee3\u8c22\u9014\u5f84\uff0c\u809d\u810f\u80bf\u7624\u75be\u75c5\uff0c\u4eba\u7c7b\u5bc4\u751f\u866b\uff08\u759f\u75be\uff09\u548c\u611f\u67d3\u6027\u75be\u75c5\u3002<\/p>\n

3.NOD-scid\u5c0f\u9f20\u4e0eIL2rg-\/-\u6742\u4ea4\u6240\u5f97\u7684\u54c1\u7cfbNOG\uff08NOD\/Shi-scid,IL-2R\u03b3null\uff09\u5c0f\u9f20\uff0c\u4e0eNOD\/scid\u5c0f\u9f20\u76f8\u6bd4\uff0cNOG\/NSG\u5c0f\u9f20\u7684\u4eba\u4f53\u7ec6\u80de\u548c\u7ec4\u7ec7\u79fb\u690d\u5b58\u6d3b\u7387\u663e\u8457\u63d0\u9ad8\uff0c\u540c\u65f6\u80fd\u591f\u690d\u5165\u66f4\u9ad8\u6bd4\u4f8b\u7684\u6b63\u5e38\u6216\u764c\u53d8\u4eba\u7c7b\u7ec6\u80de\u548c\u7ec4\u7ec7\u3002\u53e6\u5916\uff0cNOG\u5c0f\u9f20\u8fd8\u80fd\u6ee1\u8db3\u4f5c\u4e3a\u4eba\u7c7b\u514d\u75ab\u7cfb\u7edf\u6a21\u578b\u7684\u9700\u6c42\uff0c\u690d\u5165\u4eba\u7c7b\u9020\u8840\u5e72\u7ec6\u80de\u540e\uff0cNOG\u5c0f\u9f20\u7684\u5916\u5468\u6dcb\u5df4\u7ec4\u7ec7\u53ef\u4ee5\u4ea7\u751f\u4eba\u7c7bT\u7ec6\u80de\u3002<\/p>\n

\u56db\u3001\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u5e94\u7528\u9886\u57df<\/strong><\/p>\n

1. \u80bf\u7624\u5b66\u7814\u7a76\uff1a\u80bf\u7624\u751f\u957f\u3001\u80bf\u7624\u8f6c\u79fb\u3001\u80bf\u7624\u590d\u53d1\u53ca\u6297\u80bf\u7624\u836f\u7269\u7b5b\u9009\u7b49\u7814\u7a76\u3002\u5176\u4e2dBALB\/cNude\u5c0f\u9f20\u5728\u5efa\u7acb\u5f02\u79cd\u79fb\u690d\u7624\u6a21\u578b\u8f83\u5e38\u89c1\u3002<\/p>\n

2. \u514d\u75ab\u7cfb\u7edf\u7814\u7a76\uff1a\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u7531\u4e8e\u514d\u75ab\u529f\u80fd\u7f3a\u9677\u56e0\u6b64\u53ef\u4ee5\u7528\u4e8e\u514d\u75ab\u7cfb\u7edf\u4e2d\u5982T\u7ec6\u80de\u3001B\u7ec6\u80de\u3001NK\u7ec6\u80de\u53ca\u514d\u75ab\u76f8\u5173\u75be\u75c5\u7684\u7814\u7a76\uff0c\u5e76\u4e14BALB\/cNude\u8fd8\u53ef\u4ee5\u5236\u5907\u9ad8\u6548\u591a\u4ea7\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n

3. \u809d\u810f\u7814\u7a76\uff1a\u4e3b\u8981\u662f\u6307\u809d\u810f\u518d\u751f\u529f\u80fd\uff0c\u836f\u7269\u4ee3\u8c22\u53ca\u809d\u810f\u76f8\u5173\u75be\u75c5\u7814\u7a76\u3002<\/p>\n

4. \u611f\u67d3\u6027\u75be\u75c5\uff1a\u7531\u4e8e\u5bf9\u73af\u5883\u7ec6\u83cc\u548c\u75c5\u6bd2\u654f\u611f\uff0c\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u662f\u9002\u7528\u4e8e\u7814\u7a76\u75c5\u6bd2\u3001\u7ec6\u83cc\u611f\u67d3\u7684\u52a8\u7269\u6a21\u578b\u3002<\/p>\n

\u672c\u6587\u53c2\u8003\u8d44\u6599\u6765\u6e90\uff1aGene&Peace<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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