{"id":4387,"date":"2020-09-21T10:26:46","date_gmt":"2020-09-21T02:26:46","guid":{"rendered":"http:\/\/www.jsxtsw.com\/?p=4387"},"modified":"2020-11-20T14:24:48","modified_gmt":"2020-11-20T06:24:48","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e5%b0%8f%e9%bc%a0%e6%a8%a1%e5%9e%8b%e7%9a%84%e5%ba%94%e7%94%a8%e4%b8%8e%e7%89%b9%e7%82%b9","status":"publish","type":"post","link":"http:\/\/www.jsxtsw.com\/en\/%e7%b3%96%e5%b0%bf%e7%97%85%e5%b0%8f%e9%bc%a0%e6%a8%a1%e5%9e%8b%e7%9a%84%e5%ba%94%e7%94%a8%e4%b8%8e%e7%89%b9%e7%82%b9\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6a21\u578b\u7684\u5e94\u7528\u4e0e\u7279\u70b9"},"content":{"rendered":"<p>\u7cd6\u5c3f\u75c5\u662f\u4e00\u7ec4\u4ee5\u80f0\u5c9b\u7d20\u5206\u6ccc\u7f3a\u9677\u6216\u80f0\u5c9b\u7d20\u4f5c\u7528\u4e0d\u8db3\u6240\u81f4\u9ad8\u8840\u7cd6\u4e3a\u7279\u5f81\u7684\u4ee3\u8c22\u7d0a\u4e71\u3002\u7cd6\u5c3f\u75c5\u7684\u6162\u6027\u9ad8\u8840\u7cd6\u72b6\u6001\u4e0e\u957f\u671f\u5e76\u53d1\u75c7\u663e\u8457\u76f8\u5173\uff0c\u5373\u4f17\u591a\u5668\u5b98\u7684\u635f\u5bb3\uff0c\u529f\u80fd\u969c\u788d\u548c\u529f\u80fd\u8870\u7aed\uff0c\u7279\u522b\u662f\u80be\u810f\u3001\u773c\u3001\u795e\u7ecf\u3001\u5fc3\u810f\u548c\u8840\u7ba1\u3002<\/p>\n<p>\u636eWHO2017\u5e74\u6570\u636e\uff0c\u5168\u7403\u7ea64.25\u4ebf\u4eba\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c20-79\u5c81\u7684\u6210\u5e74\u4eba\u4e2d8.8%\u60a3\u6709\u7cd6\u5c3f\u75c5\u3002\u4e2d\u56fd\u9884\u8ba1\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u8d85\u8fc71.1\u4ebf\u4eba\uff08WHO2017\u5e74\u6570\u636e\uff09\u3002 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#339966;\">NOD\/ShiLtJ<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u2160\u578b\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u7cd6\u3001\u4f4e\u80f0\u5c9b\u7d20\u8840\u75c7\u3001\u4f24\u53e3\u6cbb\u6108\u4e0d\u826f\u3001\u80f0\u5c9b\u79fb\u690d\u7814\u7a76<\/p>\n<p>\u7279\u70b9\uff1a4-5\u5468\u51fa\u73b0\u80f0\u5c9b\u708e\uff08\u4e0e\u4eba\u7c7b\u6bd4\u8f83\u65e9\uff09\uff0c\u80f0\u5c9b\u5468\u8fb9\u51fa\u73b0\u6dcb\u5df4\u7ec6\u80de\uff0c\u968f\u540e\u5927\u91cf\u767d\u7ec6\u80de\uff08\u4e3b\u8981\u4e3aCD4+\u53caCD8+T\u7ec6\u80de\uff09\u8fdb\u5165\u6574\u4e2a\u80f0\u5c9b\uff0c\u6700\u540e\u03b2\u7ec6\u80de\u529f\u80fd\u8870\u7aed\uff0c\u51fa\u73b0\u7cd6\u5c3f\u75c5\u75c7\u72b6\uff1b<\/p>\n<p>\u96cc\u6027\u572812\u5468\u5de6\u53f3\u80f0\u817a\u80f0\u5c9b\u7d20\u4e0b\u964d\u660e\u663e\uff08\u96c4\u6027\u6bd4\u96cc\u6027\u8fdf\u51e0\u5468\uff09\uff0c\u8840\u7cd6\u6c34\u5e73\u4e0a\u5347\u5230\u5927\u4e8e250mg\/dl\uff1b\u572824-30\u546890%\u80f0\u5c9b\u03b2\u7ec6\u80de\u88ab\u7834\u574f\uff0c\u96cc\u6027\u66f4\u6613\u53d1\u5c55\u4e3a\u7cd6\u5c3f\u75c5\uff0890%\uff09\uff0c\u96c4\u6027\u4e3a50%-60%\uff1b<\/p>\n<p>NOD\u5c0f\u9f20\u51fa\u73b0\u5178\u578b\u7684\u7cd6\u5c3f\u75c5\u75c7\u72b6\uff08\u9ad8\u8840\u7cd6\u3001\u7cd6\u5c3f\u3001\u591a\u5c3f\uff09\uff0c\u5bf9\u916e\u9178\u4e2d\u6bd2\u62b5\u6297\u6027\u5f3a\uff0c\u7cd6\u5c3f\u75c5\u53d1\u75c5\u540e\u53ef\u5b58\u6d3b2-4\u5468\uff0c\u6b7b\u4e8e\u8131\u6c34\u800c\u975e\u916e\u9178\u4e2d\u6bd2\uff1b<\/p>\n<p>\u5c0f\u9f20\u7f3a\u4e4f\u6eb6\u8840\u8865\u4f53\uff0c\u542c\u529b\u4e25\u91cd\u53d7\u635f\uff0c3\u6708\u9f84\u65f6\u5df2\u6709\u4e25\u91cd\u7684\u6e10\u8fdb\u6027\u8033\u804b\uff1b<\/p>\n<p>\u751f\u6d3b\u73af\u5883\u3001\u5065\u5eb7\u72b6\u51b5\u548c\u996e\u98df\u5bf9\u57fa\u56e0\u5916\u663e\u7387\u4f1a\u4ea7\u751f\u5f3a\u70c8\u5f71\u54cd\uff0c\u7531\u4e8e\u96cc\u6027\u75c7\u72b6\u4ea7\u751f\u8f83\u65e9 \u4e14\u53d1\u75c5\u7387\u8f83\u9ad8\uff0c\u56e0\u6b64\u5e94\u7528\u66f4\u5e7f\u6cdb\uff1b<\/p>\n<p>MHC\u5355\u5143\u578b\u5bf9NOD\u5c0f\u9f20\u611f\u67d3\u7cd6\u5c3f\u75c5\u8d77\u4e3b\u8981\u4f5c\u7528\uff1b<\/p>\n<p>\u8bb8\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u4e2d\u7684\u514d\u75ab\u7f3a\u9677\u548c\u5b9a\u5411\u7a81\u53d8\u5df2\u56de\u4ea4\u5230\u4e86NOD\/ShiLtJ\u7684\u8fd1\u4ea4\u7cfb\u80cc\u666f\u4e0a\u3002<\/p>\n<p><span style=\"color: #339966;\">C57BL\/6-Ins2<sup>\u00a0Akita<\/sup>\/J<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u2160\u578b\u7cd6\u5c3f\u75c5\u3001\u975e\u80a5\u80d6\u578b\u7cd6\u5c3f\u75c5\u3001\u80f0\u5c9b\u79fb\u690d\u3001\u9ad8\u8840\u7cd6\u3001\u8840\u5185\u80f0\u5c9b\u7d20\u4e0d\u8db3<\/p>\n<p>\u7279\u70b9\uff1aC57BL\/6-Ins2Akita\/J\u975e\u80a5\u80d6\u7cd6\u5c3f\u75c5\u6a21\u578b\uff0c\u65e0\u80f0\u5c9b\u708e\uff1b<\/p>\n<p>\u643a\u5e26\u4eba\u80f0\u5c9b\u7d20\u524d\u4f53\u57fa\u56e0\uff0c\u96c4\u6027\u6bd4\u96cc\u6027\u4e25\u91cd\uff1b<\/p>\n<p>3-4\u5468\u591a\u996e\u3001\u591a\u5c3f\uff0c\u5faa\u5e8f\u6e10\u8fdb\u7684\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u5e76\u6700\u7ec8\u53d1\u5c55\u4e3a\u9ad8\u8840\u7cd6\uff1b<\/p>\n<p>\u8c37\u80f1\u7518\u80bd\u8f6c\u79fb\u9176\u5728\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\u6c34\u5e73\u4e0a\u5347\uff0c12\u5468\u4ea7\u751f\u6e10\u8fdb\u6027\u89c6\u7f51\u819c\u5f02\u5e38\uff1b<\/p>\n<p>\u53ef\u7528\u4e8e\u5916\u6e90\u80f0\u5c9b\u7d20\u7684\u4f7f\u7528\uff0c\u7528\u4e8e\u79fb\u690d\u5b9e\u9a8c\u3002<\/p>\n<p><span style=\"color: #339966;\">NOD.129S2(B6)-Casp1<sup>tm1Sesh<\/sup>\u00a0Casp4<sup>del<\/sup>\/LtJ<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u2160\u578b\u7cd6\u5c3f\u75c5\u3001\u7814\u7a76\u7cd6\u5c3f\u75c5\u5bfc\u81f4\u7684\u708e\u75c7\u8fc7\u7a0b\u4e2dIL1\u548cIL18\u7ec6\u80de\u56e0\u5b50\u7684\u6a21\u578b<\/p>\n<p>\u7279\u70b9\uff1a\u6ce8\u5165\u5b8c\u5168\u4f50\u5242\u7684\u521a\u65ad\u5976\u7684\u5c0f\u9f20\u7eaf\u5408\u5b50\u548c\u7528\u5c0f\u5242\u91cf\u94fe\u8132\u9709\u7d20\u6cbb\u7597\u7684\u524d\u671f\u7cd6\u5c3f\u75c5\u5e74\u8f7b\u96cc\u6027\uff0c\u884c\u4e3a\u4e0e\u5bf9\u7167\u9f20(\u91ce\u751f\u578b\u3001\u6742\u5408\u5b50\u6216NOD\/Lt)\u76f8\u4f3c\u3002<\/p>\n<h2>\u2161\u578b\u7cd6\u5c3f\u75c5\u5c0f\u9f20\u6a21\u578b<\/h2>\n<p><span style=\"color: #339966;\">BKS.Cg-Dock7<sup>m +\/+<\/sup>\u00a0Lepr<sup>db<\/sup>\/J(\u7626\u7d20\u53d7\u4f53\u7f3a\u4e4f)<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u2161\u578b\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u7cd6\u3001\u4f24\u53e3\u6cbb\u6108\u4e0d\u826f\u3001\u80f0\u5c9b\u7d20\u6297\u836f\u6027\u3001\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6<\/p>\n<p>\u7279\u70b9\uff1aBKS-db\u7eaf\u5408\u5b50\u57284\u5468\u5f00\u59cb\u53d1\u80d6\u8d2a\u98df\uff0c\u4e24\u5468\u51fa\u73b0\u80f0\u5c9b\u7d20\u62b5\u6297\u53ca\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\uff0c4-8\u5468\u56e0\u03b2\u7ec6\u80de\u969c\u788d\u5f00\u59cb\u51fa\u73b0\u9ad8\u8840\u7cd6\uff0c3-4\u4e2a\u6708\u8840\u7cd6\u9ad8\u5cf0\u671f\uff0c\u5bff\u547d\u4e3a8-10\u4e2a\u6708\uff1b<\/p>\n<p>\u7eaf\u5408\u7a81\u53d8\u5c0f\u9f20\u8d2a\u98df\u3001\u70e6\u8e81\u3001\u5e72\u6e34\u4e14\u591a\u5c3f\u3002BKS\u80cc\u666f\u4e0b\uff0c\u75be\u75c5\u5f88\u4e25\u91cd\u800c\u5bfc\u81f4\u8840\u7cd6\u4e0d\u53d7\u63a7\u5236\u7684\u5347\u9ad8\u548c\u751f\u4ea7\u80f0\u5c9b\u03b2\u7ec6\u80de\u7684\u80f0\u5c9b\u7d20\u4e25\u91cd\u67af\u7aed\u3002\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u65e0\u6cd5\u63a7\u5236\u8840\u7cd6\u6c34\u5e73\u548c\u8461\u8404\u7cd6\u5f02\u751f\u9176\u6d3b\u6027\u7684\u5347\u9ad8\uff1b<\/p>\n<p>BKS-db\u6742\u5408\u5b50\u7684\u4f53\u91cd\u3001\u8840\u7cd6\u548c\u8840\u6d46\u80f0\u5c9b\u7d20\u90fd\u6b63\u5e38\uff0c\u4ee3\u8c22\u6548\u7387\u63d0\u9ad8\u5e76\u4e14\u80fd\u6bd4\u5bf9\u7167\u5c0f\u9f20\u6d3b\u7684\u66f4\u957f\u3002<\/p>\n<p><span style=\"color: #339966;\">B6.BKS(D)-Lepr<sup>db<\/sup>\/J (\u7626\u7d20\u53d7\u4f53\u7f3a\u4e4f)<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u77ed\u6682\u6027\u2161\u578b\u7cd6\u5c3f\u75c5\u3001\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6\u3001\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u3001\u4f24\u53e3\u6cbb\u6108\u4e0d\u826f\u3001\u80f0\u5c9b\u7d20\u6297\u836f\u6027\u3001\u6682\u65f6\u6027\u9ad8\u8840\u7cd6<\/p>\n<p>\u7279\u70b9\uff1a\u7eaf\u5408\u5b50\u5c0f\u9f20\u57283\u81f34\u5468\u5de6\u53f3\u5f00\u59cb\u53d1\u80d6\uff0c10-14\u5929\u8840\u6d46\u80f0\u5c9b\u7d20\u6c34\u5e73\u5f00\u59cb\u4e0a\u5347\uff0c4\u81f38\u5468\u8840\u7cd6\u6c34\u5e73\u5f00\u59cb\u4e0a\u5347\uff1b<\/p>\n<p>\u60a3\u75c5\u5c0f\u9f20\u8d2a\u98df\u3001\u70e6\u8e81\u3001\u53e3\u6e34\u3001\u591a\u5c3f\u3002B6\u80cc\u666f\u4f7f\u5b83\u4eec\u572818\u81f320\u4e2a\u6708\u7684\u5bff\u547d\u4e2d\u90fd\u5b58\u5728\u80f0\u5c9b\u03b2\u7ec6\u80de\u4ee3\u507f\u6027\u589e\u751f\u548c\u8fde\u7eed\u7684\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\uff1b<\/p>\n<p>db\u6742\u5408\u5b50\u7684\u4f53\u91cd\u3001\u8840\u7cd6\u548c\u8840\u6d46\u80f0\u5c9b\u7d20\u90fd\u6b63\u5e38\uff0c\u4ee3\u8c22\u6548\u7387\u63d0\u9ad8\u5e76\u4e14\u80fd\u6bd4\u5bf9\u7167\u5c0f\u9f20\u6d3b\u5f97\u66f4\u957f\u3002<\/p>\n<p><span style=\"color: #339966;\">B6.Cg-Lep<sup>ob<\/sup>\/J(\u7626\u7d20\u7f3a\u4e4f)<\/span><\/p>\n<p>\u5e94\u7528\uff1a\u77ed\u6682\u6027\u2161\u578b\u7cd6\u5c3f\u75c5\u3001\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6\u3001\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u3001\u4f24\u53e3\u6cbb\u6108\u4e0d\u826f\u3001\u80f0\u5c9b\u7d20\u6297\u836f\u6027\u3001\u6682\u65f6\u6027\u9ad8\u8840\u7cd6<\/p>\n<p>\u7279\u70b9\uff1aB6\u80cc\u666fob\/ob\u6444\u98df\u591a\u3001\u4f4e\u6d88\u8017\uff0c4\u5468\u5f00\u59cb\u53d1\u80d6\uff0c\u53ef\u8fbe\u5230\u6b63\u5e38\u91ce\u751f\u578b\u5bf9\u7167\u9f20\u4f53\u91cd\u76843\u500d\uff1b<\/p>\n<p>3-4\u5468\u51fa\u73b0\u9ad8\u8840\u7cd6\uff0c\u4f34\u968f\u6444\u98df\u591a\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u53ca\u80a5\u80d6\u3001\u6682\u65f6\u6027\u9ad8\u8840\u7cd6\uff0c14-16\u5468\u5f00\u59cb\u51cf\u5f31\uff1b<\/p>\n<p>BKS\u80cc\u666fob\/ob\uff0c\u7cd6\u5c3f\u75c5\u8868\u578b\u4e25\u91cd\u5e76\u4f1a\u81f4\u6b7b\uff1b<\/p>\n<p>\u7ed9\u80a5\u80d6\u7684\u7eaf\u5408\u5b50\u6ce8\u5c04\u7626\u7d20\u80fd\u660e\u663e\u51cf\u8f7b\u4f53\u91cd\uff0c\u51cf\u5c11\u98df\u7269\u6444\u5165\uff0c\u589e\u52a0\u80fd\u91cf\u6d88\u8017\uff0c\u5e76\u4e14\u80fd\u591f\u6062\u590d\u96c4\u6027\u751f\u80b2\u80fd\u529b\u3002<\/p>\n<p><span style=\"color: #339966;\">C57BL\/6J DIO<\/span><\/p>\n<p>\u63d0\u4f9b\u9ad8\u8102\u9972\u6599\u53ef\u5f15\u53d1\u9ad8\u8102\u3001\u9ad8\u8840\u7cd6\u3001\u9ad8\u80f0\u7d20<\/p>\n<p>\u5e94\u7528\uff1a\u996e\u98df\u5bfc\u81f4\u7684\u4e2d\u5ea6\u9ad8\u8840\u7cd6\u3001\u996e\u98df\u5bfc\u81f4\u7684\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7\u3001\u996e\u98df\u5bfc\u81f4\u7684\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6\u3001\u996e\u98df\u5bfc\u81f4\u7684\u2161\u578b\u7cd6\u5c3f\u75c5<\/p>\n<table style=\"height: 621px;\" width=\"800\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td colspan=\"5\" valign=\"center\" width=\"263.33333333333337\"><span style=\"font-size: 12pt;\"><strong>\u4eba\u7c7b\u4e0e\u5c0f\u9f20\u6a21\u578b\u5bf9\u6bd4<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\"><strong>\u7cd6\u5c3f\u75c5\u8868\u578b<\/strong><\/td>\n<td valign=\"center\" width=\"9.333333333333329\"><strong>\u4eba\u7c7b<\/strong><\/td>\n<td valign=\"center\" width=\"14.333333333333343\"><strong>B6.<\/strong><strong>Ob<\/strong><\/td>\n<td valign=\"center\" width=\"13.333333333333343\"><strong>BKS.<\/strong><strong>db<\/strong><\/td>\n<td valign=\"center\" width=\"8.333333333333314\"><strong>B6 DIO<\/strong><\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u8bf1\u5bfc\u6216\u81ea\u53d1\u7a81\u53d8<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u81ea\u53d1\u7a81\u53d8<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u81ea\u53d1\u7a81\u53d8<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u81ea\u53d1\u7a81\u53d8<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u996e\u98df\u8bf1\u5bfc<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u53d1\u75c5\u65f6\u6bb5<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u6210\u5e74<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u5e7c\u65f6<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u5e7c\u65f6<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u6210\u5e74<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u6027\u522b<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">M,\u00a0F<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">M,\u00a0F<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">M,\u00a0F<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">M<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u9ad8\u80f0\u5c9b\u7d20\u8840\u75c7<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u4e2d\u5ea6<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u4e25\u91cd<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u4e2d\u5ea6(\u77ed\u6682\u7684)<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u6e29\u548c<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u8461\u8404\u7cd6\u4e0d\u8010\u53d7<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u662f<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u662f<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u662f<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u662f<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u9ad8\u8840\u7cd6<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u662f<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u4e2d\u5ea6(\u77ed\u6682\u7684)<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u4e25\u91cd<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u6e29\u548c\/\u00a0\u4e2d\u5ea6<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u80f0\u5c9b\u840e\u7f29<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u53ef\u53d8\u7684<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u5426\uff08\u4ec5\u589e\u751f\uff09<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u662f<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u5426<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u5f71\u54cd\u4f24\u53e3\u6108\u5408<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u662f<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u662f<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u662f<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u662f<\/td>\n<\/tr>\n<tr>\n<td valign=\"center\" width=\"62.33333333333333\">\u80be\u75c5<\/td>\n<td valign=\"center\" width=\"9.333333333333329\">\u662f<\/td>\n<td valign=\"center\" width=\"14.333333333333343\">\u5426<\/td>\n<td valign=\"center\" width=\"13.333333333333343\">\u662f\uff08\u6e29\u548c\uff09<\/td>\n<td valign=\"center\" width=\"8.333333333333314\">\u5426<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b<\/h2>\n<p>\u80a5\u80d6\u5f80\u5f80\u5148\u4e8e\u7cd6\u5c3f\u75c5\u51e0\u5e74\u3001\u5341\u51e0\u5e74\u6216\u4e8c\u5341\u51e0\u5e74\uff0c\u91cd\u5ea6\u80a5\u80d6\u8005\u53d1\u751f\u7cd6\u5c3f\u75c5\u51e0\u7387\u6bd4\u6b63\u5e38\u4f53\u91cd\u8005\u589e\u52a010\u500d\uff0c75%\u7684\u2161\u578b\u7cd6\u5c3f\u75c5\u8bf1\u56e0\u4e3a\u80a5\u80d6\uff0c\u4f46\u4e0d\u610f\u5473\u7740\u6240\u6709\u80a5\u80d6\u8005\u90fd\u4f1a\u53d1\u5c55\u4e3a\u7cd6\u5c3f\u75c5\u3002<\/p>\n<p><span style=\"color: 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#339966;\">B6.129P2-Apoe<sup>tm1Unc<\/sup><\/span><\/p>\n<p>\u5e94\u7528\uff1a\u996e\u98df\u8bf1\u5bfc\u7684\u975e\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6\u6a21\u578b\u3001\u9ad8\u8102\u8840\u75c7\u3001\u8111\u6897\u585e\u3001AD<\/p>\n<p>\u7279\u70b9\uff1aAPOE\u5c0f\u9f20\u8840\u6d46\u80c6\u56fa\u9187\u6c34\u5e73\u660e\u663e\u4e0a\u5347\uff0c\u4e14\u4e0d\u53d7\u5e74\u9f84\u53ca\u6027\u522b\u5f71\u54cd\uff1b<\/p>\n<p>3\u6708\u9f84\u5728\u4e3b\u52a8\u8109\u9644\u8fd1\u53d1\u73b0\u8102\u80aa\u7eb9\uff0c\u8fd9\u5c06\u5bf9\u673a\u4f53\u9020\u6210\u635f\u5bb3\uff0c\u8fd9\u79cd\u635f\u5bb3\u4f1a\u968f\u5e74\u9f84\u589e\u957f\u548c\u8102\u8d28\u51cf\u5c11\u800c\u589e\u52a0\uff1b<\/p>\n<p>17\u6708\u9f84\u65f6\u5c0f\u9f20\u8111\u5185\u5c06\u51fa\u73b0\u8102\u7624\u6027\u7ea4\u7ef4\u7624\uff0c\u540c\u65f6\u8fd8\u6709\u8102\u8d28\u5c0f\u7403\u548c\u6ce1\u6cab\u7ec6\u80de\uff1b<\/p>\n<p>\u5bf9\u5e94\u6fc0\u3001\u5b66\u4e60\u4e0e\u8bb0\u5fc6\u53d7\u635f\u3001\u7a81\u51fa\u635f\u4f24\u90fd\u6709\u53cd\u5e94\u3002<\/p>\n<p><span style=\"color: #339966;\">B6.129S4-Itgam<sup>tm1<\/sup><\/span><\/p>\n<p>\u5e94\u7528\uff1a\u6210\u5e74\u578b\u975e\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6<\/p>\n<p>\u7279\u70b9\uff1a\u5728\u708e\u75c7\u8fc7\u7a0b\u4e2d\uff0c\u5c0f\u9f20\u6574\u5408\u7d20\u03b1M\u8868\u8fbe\u7f3a\u5931\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6d3b\u5316\u51cf\u5c11\uff1b<\/p>\n<p>\u7eaf\u5408\u5c0f\u9f20\u5bf9\u5927\u8111\u7f3a\u8840\u654f\u611f\u5ea6\u964d\u4f4e\uff0c\u5bf9\u6cf0\u7d20\u4ecb\u5bfc\u7684\u57fa\u56e0\u8868\u8fbe\u5e94\u7b54\u964d\u4f4e\u3002<\/p>\n<p><span style=\"color: #339966;\">B6;129S-Tnf<sup>tm1Gkl<\/sup><\/span><\/p>\n<p>\u5e94\u7528\uff1a\u975e\u7cd6\u5c3f\u75c5\u578b\u80a5\u80d6\u6a21\u578b<\/p>\n<p>\u7279\u70b9\uff1a\u7eaf\u5408\u7a81\u53d8\u5c0f\u9f20\u6dcb\u5df4\u7ed3\u548c\u6dcb\u5df4\u96c6\u7ed3\u53d1\u80b2\u6b63\u5e38\uff0c\u5c0f\u9f20\u5916\u89c2\u8868\u578b\u6b63\u5e38\uff1b<\/p>\n<p>\u7eaf\u5408\u7a81\u53d8\u5c0f\u9f20\u65e0\u813eB\u7ec6\u80de\u6ee4\u6ce1\uff0c\u4e0d\u80fd\u5f62\u6210\u5c0f\u7ed3\u6811\u7a81\u7ec6\u80de\uff1b<\/p>\n<p>\u4e0d\u80a5\u80d6\u7684\u7eaf\u5408\u7a81\u53d8\u5c0f\u9f20\uff0c\u5176\u4f53\u91cd\u3001\u9644\u777e\u8102\u80aa\u91cd\u91cf\u548c\u4f53\u8102\u6bd4\u90fd\u5448\u73b0\u4e2d\u7b49\u7a0b\u5ea6\u4e0b\u964d\u300228\u5468\u7684\u7a81\u53d8\u96c4\u9f20\u4e0e\u91ce\u751f\u5bf9\u7167\u9f20\u76f8\u6bd4\uff0c\u80f0\u5c9b\u7d20\u3001\u7518\u6cb9\u4e09\u916f\u548c\u7626\u7d20\u6c34\u5e73\u66f4\u4f4e\uff1b<\/p>\n<p>\u7528\u6765\u8bf1\u5bfc\u76ae\u80a4\u7624\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u7f3a\u5931\u5c0f\u9f20\u53d1\u751f\u826f\u6027\u548c\u6076\u6027\u80bf\u7624\u660e\u663e\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\u5c11\uff1b<\/p>\n<p>\u7ed3\u679c\u8868\u660eTNF\u5728\u8102\u8d28\u548c\u8461\u8404\u7cd6\u4ee3\u8c22\u4e2d\u6709\u4e00\u5b9a\u4f5c\u7528\uff0c\u4f46\u5728\u8bf1\u5bfc\u80a5\u80d6\u6a21\u578b\u4e2d\u5e76\u4e0d\u80fd\u5b8c\u5168\u6e05\u9664\u9ad8\u8840\u7cd6\u548c\u8840\u80f0\u5c9b\u7d20\u8fc7\u9ad8\u3002<\/p>\n<p><span 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