{"id":4819,"date":"2020-11-05T17:08:23","date_gmt":"2020-11-05T09:08:23","guid":{"rendered":"http:\/\/www.ychljhotel.com\/?p=4819"},"modified":"2020-11-20T14:39:59","modified_gmt":"2020-11-20T06:39:59","slug":"mcd%e9%a5%b2%e6%96%99%e8%af%b1%e5%af%bc%e5%a4%a7%e3%80%81%e5%b0%8f%e9%bc%a0nash%e6%a8%a1%e5%9e%8b%e7%9a%84%e5%af%b9%e6%af%94%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"http:\/\/www.ychljhotel.com\/en\/mcd%e9%a5%b2%e6%96%99%e8%af%b1%e5%af%bc%e5%a4%a7%e3%80%81%e5%b0%8f%e9%bc%a0nash%e6%a8%a1%e5%9e%8b%e7%9a%84%e5%af%b9%e6%af%94%e7%a0%94%e7%a9%b6\/","title":{"rendered":"MCD\u9972\u6599\u8bf1\u5bfc\u5927\u3001\u5c0f\u9f20NASH\u6a21\u578b\u7684\u5bf9\u6bd4\u7814\u7a76"},"content":{"rendered":"<p>\u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u662f\u4e00\u79cd\u65e0\u8fc7\u91cf\u996e\u9152\uff0c\u4ee5\u809d\u810f\u7ec6\u80de\u8102\u80aa\u53d8\u6027\u3001\u6c14\u7403\u6837\u53d8\u3001\u5f25\u6563\u6027\u809d\u5c0f\u53f6\u708e\u75c7\u4e3a\u4e3b\u8981\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u7684\u7efc\u5408\u5f81\u3002\u5b83\u662f\u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u53d1\u5c55\u4e3a\u809d\u786c\u5316\u548c\u809d\u764c\u7684\u4e00\u4e2a\u91cd\u8981\u9636\u6bb5\u3002\u636e\u62a5\u9053NAFLD\u5728\u53d1\u8fbe\u56fd\u5bb6\u7684\u53d1\u75c5\u7387\u8868\u73b0\u4e3a\u6210\u4eba30%\u3001\u513f\u7ae513%\uff0c\u5176\u4e2d\u5927\u7ea6\u670910%\u7684NAFLD\u60a3\u8005\u53d1\u5c55\u6210\u4e3aNASH\uff0c\u800cNASH\u60a3\u8005\u4e2d\u768410%\u4f1a\u53d1\u5c55\u6210\u4e3a\u809d\u786c\u5316\uff0c\u751a\u81f3\u809d\u764c\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-4823 aligncenter\" src=\"http:\/\/www.ychljhotel.com\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201013094021.jpg\" alt=\"\" width=\"804\" height=\"490\" srcset=\"http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201013094021.jpg 804w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201013094021-500x305.jpg 500w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201013094021-768x468.jpg 768w\" sizes=\"(max-width: 804px) 100vw, 804px\" \/><\/p>\n<p>\u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u708e\u5df2\u7ecf\u6210\u4e3a\u7814\u7a76\u7684\u7126\u70b9\uff0c\u7136\u800cNASH\u7684\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u660e\u786e\uff0c\u7814\u7a76\u53d1\u73b0\u5176\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u7626\u7d20\u3001Kupffer\u7ec6\u80de\u7b49\u591a\u79cd\u56e0\u7d20\u76f8\u5173\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u7684\u836f\u7269\u666e\u904d\u5b58\u5728\u6bd2\u526f\u4f5c\u7528\u8f83\u5927\u3001\u4ef7\u683c\u6602\u8d35\u7b49\u95ee\u9898\uff0c\u800c\u88ab\u8bc1\u5b9e\u7684\u6709\u6548\u4e14\u65e0\u526f\u4f5c\u7528\u6cbb\u7597\u65b9\u6cd5\u4ec5\u6709\u9002\u5f53\u7684\u6e10\u8fdb\u6027\u51cf\u80a5\u8fd0\u52a8\u8fd9\u4e00\u9879\u3002 \u56e0\u6b64\u63a2\u7d22\u65b0\u578b\u65e0\u6bd2\u526f\u4f5c\u7528\u836f\u7269\u5bf9\u5176NASH\u4e34\u5e8a\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u800c\u53ef\u9760\u7684\u52a8\u7269\u6a21\u578b\u5bf9\u63a2\u7d22NASH\u7684\u53d1\u75c5\u673a\u5236\u53ca\u9632\u6cbb\u53d1\u6325\u7740\u5173\u952e\u6027\u4f5c\u7528\u3002<\/p>\n<p><strong>\u76ee\u524d\u56fd\u5185\u5916\u7684NASH\u6a21\u578b\u4e3b\u8981\u5305\u62ec3\u7c7b\uff1a<\/strong><\/p>\n<p>\u2460 \u8425\u517b\u5931\u8c03\u6027\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\uff0c\u5b83\u5305\u62ec\u4e86\u9ad8\u8102\u996e\u98df\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u9ad8\u7cd6\u996e\u98df\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u548c\u86cb\u6c28\u9178\u80c6\u78b1\u7f3a\u4e4f\uff08MCD\uff09\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3002<\/p>\n<p>\u2461 \u590d\u5408\u56e0\u7d20\u8bf1\u5bfc\u7684NASH\u6a21\u578b\uff0c\u4e3b\u8981\u662f\u4ee5\u9ad8\u8102\u80aa\u9972\u6599\u52a0\u5316\u5b66\u836f\u7269\u6765\u8fdb\u884c\u9020\u6a21\uff0c\u5305\u62ec\u56db\u6c2f\u5316\u78b3\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u56db\u73af\u7d20\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u4e59\u786b\u6c28\u9178\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3002<\/p>\n<p>\u2462 \u7279\u6b8a\u54c1\u7cfb\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\uff0c\u4e3b\u8981\u6709\u7626\u7d20\u7f3a\u4e4f\u548c\u62b5\u6297\u5c0f\u9f20\u6a21\u578b\u3001<em>PTEN<\/em>\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u6a21\u578b\u3002\u5176\u4e2d\uff0cMCD\u9972\u6599\u8bf1\u5bfc\u7684NASH\u6a21\u578b\u662f\u76ee\u524d\u56fd\u9645\u4e0a\u88ab\u5e7f\u6cdb\u8ba4\u53ef\u7684\u6a21\u578b\u3002<\/p>\n<p>\u8be5\u6a21\u578b\u6700\u65e9\u7531Shinozuka\u63d0\u51fa\uff0c\u8d77\u521d\u662f\u7528\u4e8e\u63a2\u8ba8\u996e\u98df\u56e0\u7d20\u5bf9\u809d\u810f\u80bf\u7624\u5f62\u6210\u7684\u5f71\u54cd\uff0c\u540e\u6765\u53d1\u73b0\u5728\u77ed\u671f\u5185\u53ef\u4ee5\u5f15\u8d77\u8102\u80aa\u6027\u809d\u708e\u3002\u8be5\u6a21\u578b\u7684\u8102\u80aa\u6027\u809d\u708e\u53d1\u5c55\u901f\u5ea6\u5feb\uff0c\u5176\u75c5\u7406\u75c5\u53d8\u4e0e\u4eba\u7c7b\u7684NASH\u7c7b\u4f3c\uff0c\u56e0\u6b64\u6210\u4e3a\u8fd1\u5e74\u6765\u56fd\u5185\u5916\u5b66\u8005\u7814\u7a76NASH\u7684\u70ed\u70b9\u6a21\u578b\uff0c\u4f46\u672a\u89c1\u5173\u4e8e\u5728\u5927\u5c0f\u9f20\u4f53\u5185\u7528MCD\u9972\u6599\u8bf1\u5bfcNASH\u6a21\u578b\u5dee\u5f02\u6bd4\u8f83\u7684\u62a5\u9053\u3002<\/p>\n<p>\u672c\u7814\u7a76\u65e8\u5728\u901a\u8fc7MCD\u9972\u6599\u5206\u522b\u5efa\u7acb\u5927\u3001\u5c0f\u9f20NASH\u6a21\u578b\uff0c\u6bd4\u8f83\u5176\u751f\u5316\u548c\u75c5\u7406\u6307\u6807\uff0c\u63a2\u8ba8\u4e24\u79cd\u52a8\u7269\u6a21\u578b\u7684\u5dee\u5f02\uff0c\u4e3aNASH\u7684\u57fa\u7840\u7814\u7a76\u548c\u9632\u6cbb\u836f\u7269\u7684\u5f00\u53d1\u63d0\u4f9b\u53ef\u9760\u7684\u52a8\u7269\u6a21\u578b\u3002<\/p>\n<p><strong>\u5b9e\u9a8c\u52a8\u7269\u4e0e\u65b9\u6848<\/strong><\/p>\n<p><span style=\"color: #339966;\">\u5b9e\u9a8c\u52a8\u7269<\/span><\/p>\n<p>SPF\u7ea7C57BL\/6\u96c4\u6027\u5c0f\u9f2018\u53ea\uff0c8~9\u5468\u9f84\uff0c\u4f53\u91cd\u4e3a22~25 g\uff1bSPF\u7ea7SD\u96c4\u6027\u5927\u9f2018\u53ea\uff0c8~9\u5468\u9f84\uff0c\u4f53\u91cd\u4e3a300~350g\u3002\u9972\u517b\u4e8e\u9075\u4e49\u533b\u5b66\u9662\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\uff0c\u5c4f\u969c\u73af\u5883\u52a8\u7269\u623f\u5ba4\u6e29\uff0822 \u00b11\uff09\u00b0 \uff0c\u76f8\u5bf9\u6e7f\u5ea630%~60%\uff0c12h\u5149\u7167\/12h\u9ed1\u6697\uff0c\u52a8\u7269\u81ea\u7531\u91c7\u98df\u548c\u996e\u6c34\u3002<\/p>\n<p><span style=\"color: #339966;\">\u5b9e\u9a8c\u8bd5\u5242<\/span><\/p>\n<p>\u68c0\u6d4b\u8c37\u4e19\u8f6c\u6c28\u9176\uff08ALT\uff09\u3001\u8c37\u8349\u8f6c\u6c28\u9176\uff08AST\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u548c\u80c6\u56fa\u9187\uff08TC\uff09\u542b\u91cf\u7684\u8bd5\u5242\u76d2\uff0c\u5747\u8d2d\u81ea\u5fb7\u56fd\u7f57\u6c0f\u8bca\u65ad\u516c\u53f8\uff0c\u6309\u8bf4\u660e\u4e66\u548c\u6587\u732e\u62a5\u9053\u7684\u65b9\u6cd5\u8fdb\u884c\u68c0\u6d4b\u3002<\/p>\n<p><span style=\"color: #339966;\">\u52a8\u7269\u9972\u6599<\/span><\/p>\n<p>\u86cb\u6c28\u9178\u80c6\u78b1\u7f3a\u4e4f\uff08MCD\uff09\u9972\u6599\u548c\u86cb\u6c28\u9178\u80c6\u78b1\u5145\u8db3\uff08MCS\uff09\u9972\u6599\uff0c\u6839\u636e\u9972\u6599\u751f\u4ea7\u516c\u53f8\u6280\u672f\u4eba\u5458\u7684\u6307\u5bfc\u8fdb\u884c\u9972\u517b\u3002<\/p>\n<p><span style=\"color: #339966;\">\u52a8\u7269\u5206\u7ec4<\/span><\/p>\n<p>\u5c0618\u53eaC57BL\/6\u5c0f\u9f20\u548c18\u53eaSD\u5927\u9f20\u5206\u522b\u968f\u673a\u5206\u6210\u6b63\u5e38\u7ec4\uff08\u9972\u5582MCS\u9972\u6599\uff09\u548c\u6a21\u578b\u7ec4\uff08\u9972\u5582MCD\u9972\u6599\uff09\u3002\u6a21\u578b\u7ec4\u9700\u89811\u5468\u8fc7\u6e21\u6027\u9972\u6599\u7684\u5582\u517b\uff0c\u7b2c1 ~3\u5929\u5c06MCS\u548c MCD\u9972\u6599\u63092:1\u6df7\u5408\u540e\u5582\u517b\uff0c\u7b2c4 ~5\u5929\u63091:1\u6df7\u5408\u5582\u517b\uff0c\u7b2c6-7\u5929\u63091:2\u6df7\u5408\u5582\u517b\uff0c1\u5468\u540e\u5b8c\u5168\u6295\u5582MCD\u9972\u6599\u3002\u8fc7\u6e21\u6027\u9972\u517b\u540e\u7684\u7b2c3\u30015\u30018\u5468\u5728\u5404\u7ec4\u4e2d\u5206\u522b\u968f\u673a\u9009\u53d66\u53ea\u52a8\u7269\u6837\u672c\uff0c\u8fdb\u884c\u809d\u529f\u80fd\u751f\u5316\u6307\u6807\u548c\u809d\u810f\u75c5\u7406\u7684\u68c0\u6d4b\u3002\u4ece\u8fc7\u6e21\u9972\u5582\u5f00\u59cb\u4e14\u6bcf\u5468\u79f0\u91cf\u52a8\u7269\u4f53\u8d28\u91cf\uff08g\uff09\u5e76\u8bb0\u5f55\u3002<\/p>\n<p><strong>\u5b9e\u9a8c\u7ed3\u679c<\/strong><\/p>\n<p><span style=\"color: #339966;\">\u4f53\u8d28\u91cf\u53d8\u5316<\/span><\/p>\n<p>\u6b63\u5e38\u5bf9\u7167\u7ec4\u5b9e\u9a8c\u52a8\u7269\u7684\u4f53\u8d28\u91cf\u6301\u7eed\u589e\u957f\uff0c\u6a21\u578b\u7ec4\u5b9e\u9a8c\u52a8\u7269\u4f53\u8d28\u91cf\u9010\u6e10\u51cf\u8f7b\uff1b\u4ece\u7b2c 3\u5468\u5f00\u59cb\uff0c\u76f8\u6bd4\u4e8e\u6b63\u5e38\u7ec4\uff0c\u6a21\u578b\u7ec4\u7684\u5b9e\u9a8c\u52a8\u7269\u4f53\u8d28\u91cf\u90fd\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-4820\" src=\"http:\/\/www.ychljhotel.com\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162817.png\" alt=\"\" width=\"813\" height=\"183\" srcset=\"http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162817.png 813w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162817-500x113.png 500w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162817-768x173.png 768w\" sizes=\"(max-width: 813px) 100vw, 813px\" \/><\/p>\n<p><span style=\"color: #339966;\">\u52a8\u7269\u8840\u6e05\u4e2dALT\u3001AST\u3001TC\u548cTG\u7684\u542b\u91cf<\/span><\/p>\n<p>\u4ece\u7b2c3\u5468\u5f00\u59cb\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u9176AST\u548cALT\u6c34\u5e73\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c\u5747\u5df2\u663e\u8457\u5347\u9ad8\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5927\u9f20\u6a21\u578b\u7ec4\u5728\u68c0\u6d4b\u76843\u4e2a\u65f6\u95f4\u70b9\uff0c\u809d\u9176AST\u6c34\u5e73\u65e0\u663e\u8457\u53d8\u5316\uff0c\u800cALT\u6c34\u5e73\u4ece\u7b2c3\u5468\u5f00\u59cb\u663e\u8457\u5347\u9ad8\u3002\u5728\u68c0\u6d4b\u7684\u9020\u6a21\u540e\u7b2c3\u5468\u30015\u5468\u30018 \u5468\uff0c\u5927\u3001\u5c0f\u9f20\u8840\u6e05\u4e2dTG\u548cTC\u542b\u91cf\u5747\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-4821 aligncenter\" src=\"http:\/\/www.ychljhotel.com\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162834.png\" alt=\"\" width=\"818\" height=\"379\" srcset=\"http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162834.png 818w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162834-500x232.png 500w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105162834-768x356.png 768w\" sizes=\"(max-width: 818px) 100vw, 818px\" \/><\/p>\n<p><span style=\"color: #339966;\">\u809d\u7ec4\u7ec7HE\u67d3\u8272<\/span><\/p>\n<p>\u6b63\u5e38\u5bf9\u7167\u7ec4\u809d\u5c0f\u53f6\u7ed3\u6784\u6e05\u6670\u3001\u5b8c\u6574\uff0c\u809d\u7ec6\u80de\u4ee5\u4e2d\u592e\u9759\u8109\u4e3a\u4e2d\u5fc3\uff0c\u5448\u653e\u5c04\u72b6\u6392 \u5217,\u65e0\u809d\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u6216\u708e\u75c7\u7ec6\u80de\u6d78\u6da6\uff08\u89c1\u56fe1A\u3001C\uff09\u3002MCD\u9972\u6599\u9972\u55828\u5468\u540e\uff0c\u6a21\u578b\u7ec4\u7684\u5927\u9f20\u809d\u7ec4\u7ec7\u5c0f\u53f6\u7ed3\u6784\u5df2\u88ab\u7834\u574f\uff0c\u5927\u6ce1\u6027\u6c14\u7403\u6837\u53d8\u7ec6\u80de\u5360\u4e86\u603b\u7ec6\u80de\u76842\/3\u4ee5\u4e0a\uff0c\u4ee5\u809d\u5c0f\u53f6\u5468\u8fb9\u8102\u80aa\u53d8\u6027\u6700\u4e3a\u4e25\u91cd\uff0c \u5c40\u90e8\u53ef\u89c1\u5927\u6ce1\u6027\u6c14\u7403\u6837\u53d8\u548c\u4ee5\u5355\u4e2a\u6838\u7ec6\u80de\u6d78\u6da6\u4e3a\u4e3b\u708e\u75c7\u53cd\u5e94\uff08\u89c1\u56fe1B\uff09\u30028\u5468\u65f6\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u5149\u955c\u4e0b\u89c1\u809d\u5c0f\u53f6\u7ed3\u6784\u7d0a\u4e71\uff0c\u7ec6\u80de\u51fa\u73b0\u4e25\u91cd\u7684\u8102\u80aa\u53d8 \u6027\uff0c\u4e2d\u592e\u9759\u8109\u5468\u56f4\u51fa\u73b0\u4e25\u91cd\u3001\u4ee5\u6d78\u6da6\u4e3a\u4e3b\u7684\u5c40\u7076\u574f \u6b7b\u6027\u708e\u75c7\uff08\u89c1\u56fe1D\uff09\u3002\u5177\u4f53NAFLD\u6d3b\u52a8\u5ea6\u79ef\u5206\u89c1\u88683\uff0cSD\u5927\u9f20\u548cC57BL\/6\u5c0f\u9f20\u7efc\u5408\u8bc4\u5206\u5747\u8868\u73b0\u4e3a\u6a21\u578b\u7ec4\u4e0e\u6b63\u5e38\u7ec4\u4e4b\u95f4\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P&lt; 0. 05\uff09\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-4822 aligncenter\" src=\"http:\/\/www.ychljhotel.com\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105164029.jpg\" alt=\"\" width=\"802\" height=\"426\" srcset=\"http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105164029.jpg 802w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105164029-500x266.jpg 500w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2020\/11\/\u5fae\u4fe1\u56fe\u7247_20201105164029-768x408.jpg 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><\/p>\n<p><strong>\u5b9e\u9a8c\u8ba8\u8bba<\/strong><\/p>\n<p>MCD\u9972\u6599\u8bf1\u5bfc\u7684NASH\u6a21\u578b\u7684\u4e3b\u8981\u53d1\u75c5\u673a\u5236\u662f\u7531\u4e8e\u9972\u6599\u7f3a\u4e4f\u80c6\u78b1\u800c\u5f15\u8d77\u673a\u4f53\u5375\u78f7\u8102\u5408\u6210\u4e0d\u8db3\u3002\u86cb\u6c28\u9178\u4e3a\u5408\u6210\u8f7d\u8102\u86cb\u767d\u6240\u5fc5\u9700\u7684\u6c28\u57fa\u9178\uff0c\u7f3a\u4e4f \u9178\u4f1a\u5bfc\u81f4\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u5408\u6210\u51cf\u5c11\uff0c\u56e0\u6b64\u65e0\u6cd5 \u5c06\u4e09\u9170\u7518\u6cb9\u8fd0\u51fa\u809d\u5916\u800c\u7d2f\u79ef\u5f62\u6210\u8102\u80aa\u809d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7f3a\u4e4f\u80c6\u78b1\u8fd8\u4f1a\u5f15\u8d77\u809d\u810f\u7ebf\u7c92\u4f53\u5185\u90e8\u6d3b\u6027\u6c27\u589e\u52a0\uff0c\u6700\u7ec8\u5bfc\u81f4\u6c27\u5e94\u6fc0\u589e\u52a0\u800c\u809d\u810f\u53d1\u751f\u635f\u4f24\u3002\u6c27\u5e94\u6fc0\u4e0d\u4f46\u5bfc\u81f4\u7ec6\u80de\u591a\u79cd\u529f\u80fd\u548c\u7ed3\u6784\u635f\u4f24\uff0c\u800c\u4e14\u6d3b\u5316TNF\u03b1\u53ca\u5176\u4ed6\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50<sup><sub>\u3002<\/sub><\/sup><\/p>\n<p>\u8be5\u6a21\u578b\u81ea1978\u5e74Shinozuka\u63d0\u51fa\u4ee5\u6765\uff0c\u88ab\u56fd\u5185\u5916\u7684\u5b66\u8005\u5e7f\u6cdb\u5e94\u7528\u4e8e\u836f\u7269\u7b5b\u9009\uff0c\u4f46\u662f\u7f3a\u5c11\u6587\u732e\u5bf9\u8be5\u6a21\u578b\u5728C57BL\/6\u5c0f\u9f20\u548cSD\u5927\u9f20\u7684\u7cfb\u7edf\u6027\u62a5\u9053\u3002\u4e8e\u662f\u672c\u5b9e\u9a8c\u9972\u5582MCD\u9972\u6599\u5efa\u7acb\u5927\u3001\u5c0f\u9f20NASH\u6a21\u578b\uff0c\u5bf9\u5176\u8840\u6db2\u7684\u751f\u5316\u6307\u6807\u548c\u809d\u810f\u7684\u75c5\u7406\u6307\u6807\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u65e8\u5728\u63a2\u8ba8\u4e24\u79cd\u52a8\u7269\u6a21\u578b\u7684\u751f\u5316\u548c\u75c5\u7406\u5dee\u5f02\uff0c\u4ee5\u9009\u62e9\u7406\u60f3\u7684\u52a8\u7269\u6a21\u578b\u3002<\/p>\n<p>\u672c\u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0c\u5728\u809d\u635f\u4f24\u6307\u6570\u65b9\u9762\uff0c\u9972\u5582MCD\u9972\u6599\u7684\u7b2c3\u5468\u5f00\u59cb\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u7684\u809d\u9176AST\u3001 ALT\u6c34\u5e73\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\u5df2\u7ecf\u663e\u8457\u5347\u9ad8\uff0c\u4f46\u6a21\u578b\u5927\u9f20 AST\u6c34\u5e73\u4ece\u5b9e\u9a8c\u5f00\u59cb\u81f3\u7ed3\u675f\u4ecd\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u800cAST\u548cALT\u7684\u6c34\u5e73\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u901a\u5e38\u4f5c\u4e3a\u809d\u810f\u529f\u80fd\u8bc4\u4ef7\u91cd\u8981\u6307\u6807\uff0c\u53cd\u6620\u8102\u80aa\u809d\u7684\u65e9\u671f\u635f\u5bb3\uff0c\u56e0\u6b64\u8868\u660eC57BL\/6\u5c0f\u9f20\u5bf9MCD\u9972\u6599\u7684\u53cd\u5e94\u5728\u65e9\u671f\u6bd4SD\u5927\u9f20\u66f4\u654f\u611f \uff0c\u66f4\u5bb9\u6613\u5f15\u8d77\u809d\u635f\u4f24\u809d \u3002<\/p>\n<p>\u800c\u4e14\u809d\u7ec4\u7ec7\u75c5\u7406\u7ed3\u679c\u663e\u793a\uff0c\u9972\u5582MCD\u9972\u65998\u5468\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u6bd4\u5927\u9f20\u51fa\u73b0\u7684\u8102\u80aa\u53d8\u6027\u66f4\u4e25\u91cd\uff0c\u5c0f\u533a\u57df\u51fa\u73b0\u5c0f\u6ce1\u4e3a\u4e3b\u7684\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u53ca\u8f7b\u5fae\u7684\u708e\u75c7\u53cd\u5e94\uff1b\u540c\u65f6\u901a\u8fc7\u809d\u7ec4\u7ec7\u75c5\u4f8b\u8bc4\u5206\u7ed3\u679c\u8868\u660e8\u5468\u540e\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u708e\u75c7\u53cd\u5e94\u53ca\u8102\u80aa\u53d8\u6027\u7b49\u75c5\u7406\u7279\u5f81\u7684\u5f97\u5206\u660e\u663e\u9ad8\u4e8e\u5927\u9f20\u3002\u53e6\u5916\uff0c\u5c0f\u9f20\u5177\u6709\u91c7\u98df\u91cf\u5c11\u3001\u6210\u672c\u4f4e\u53ca\u64cd\u4f5c\u65b9\u4fbf\u7b49\u4f18\u70b9\u3002\u56e0\u6b64\uff0c\u7efc\u5408\u751f\u5316\u6307\u6807\u53ca\u75c5\u7406\u7279\u5f81\u7b49\u56e0\u7d20\uff0c<a href=\"http:\/\/www.ychljhotel.com\/4537\/\">MCD\u9972\u6599<\/a>\u8bf1\u5bfc\u7684C57BL\/6\u5c0f\u9f20\u6a21\u578b\u6bd4SD\u5927\u9f20\u6a21\u578b\u66f4\u9002\u7528\u4e8e\u8fdb\u4e00\u6b65\u7814\u7a76NASH.<\/p>\n<p><span style=\"font-size: 10pt; color: #808080;\">\u672c\u6587\u4f5c\u8005\uff1a\u5d14\u56fd\u796f\/\u4f59\u6c49\u6fe0\/\u9ec4\u5929\u517b\/\u738b\u6587\/\u5f90\u4e49\u7965\/\u7a0b\u81ea\u521a\/\u5434\u5f69\u71d5\/\u674e\u94ed\u6e90\uff0c\u9075\u4e49\u533b\u5b66\u9662<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u662f\u4e00\u79cd\u65e0\u8fc7\u91cf\u996e\u9152\uff0c\u4ee5\u809d\u810f\u7ec6\u80de\u8102\u80aa\u53d8\u6027\u3001\u6c14\u7403\u6837\u53d8\u3001\u5f25\u6563\u6027\u809d\u5c0f\u53f6\u708e\u75c7\u4e3a\u4e3b\u8981\u4e34\u5e8a\u75c5\u7406\u7279\u5f81\u7684\u7efc\u5408\u5f81\u3002\u5b83\u662f\u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u53d1\u5c55\u4e3a\u809d\u786c\u5316\u548c\u809d\u764c\u7684\u4e00\u4e2a\u91cd\u8981\u9636\u6bb5\u3002\u636e\u62a5\u9053NAFLD\u5728\u53d1\u8fbe\u56fd\u5bb6\u7684\u53d1\u75c5\u7387\u8868\u73b0\u4e3a\u6210\u4eba30%\u3001\u513f\u7ae513%\uff0c\u5176\u4e2d\u5927\u7ea6\u670910%\u7684NAFLD\u60a3\u8005\u53d1\u5c55\u6210\u4e3aNASH\uff0c\u800cNASH\u60a3\u8005\u4e2d\u768410%\u4f1a\u53d1\u5c55\u6210\u4e3a\u809d\u786c\u5316\uff0c\u751a\u81f3\u809d\u764c\u3002 \u975e\u9152\u7cbe\u8102\u80aa\u6027\u809d\u708e\u5df2\u7ecf\u6210\u4e3a\u7814\u7a76\u7684\u7126\u70b9\uff0c\u7136\u800cNASH\u7684\u53d1\u75c5\u673a\u5236\u5c1a\u672a\u660e\u786e\uff0c\u7814\u7a76\u53d1\u73b0\u5176\u4e0e\u80f0\u5c9b\u7d20\u62b5\u6297\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u7626\u7d20\u3001Kupffer\u7ec6\u80de\u7b49\u591a\u79cd\u56e0\u7d20\u76f8\u5173\u3002\u76ee\u524d\u4e34\u5e8a\u4e0a\u7684\u836f\u7269\u666e\u904d\u5b58\u5728\u6bd2\u526f\u4f5c\u7528\u8f83\u5927\u3001\u4ef7\u683c\u6602\u8d35\u7b49\u95ee\u9898\uff0c\u800c\u88ab\u8bc1\u5b9e\u7684\u6709\u6548\u4e14\u65e0\u526f\u4f5c\u7528\u6cbb\u7597\u65b9\u6cd5\u4ec5\u6709\u9002\u5f53\u7684\u6e10\u8fdb\u6027\u51cf\u80a5\u8fd0\u52a8\u8fd9\u4e00\u9879\u3002 \u56e0\u6b64\u63a2\u7d22\u65b0\u578b\u65e0\u6bd2\u526f\u4f5c\u7528\u836f\u7269\u5bf9\u5176NASH\u4e34\u5e8a\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u800c\u53ef\u9760\u7684\u52a8\u7269\u6a21\u578b\u5bf9\u63a2\u7d22NASH\u7684\u53d1\u75c5\u673a\u5236\u53ca\u9632\u6cbb\u53d1\u6325\u7740\u5173\u952e\u6027\u4f5c\u7528\u3002 \u76ee\u524d\u56fd\u5185\u5916\u7684NASH\u6a21\u578b\u4e3b\u8981\u5305\u62ec3\u7c7b\uff1a \u2460 \u8425\u517b\u5931\u8c03\u6027\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\uff0c\u5b83\u5305\u62ec\u4e86\u9ad8\u8102\u996e\u98df\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u9ad8\u7cd6\u996e\u98df\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u548c\u86cb\u6c28\u9178\u80c6\u78b1\u7f3a\u4e4f\uff08MCD\uff09\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3002 \u2461 \u590d\u5408\u56e0\u7d20\u8bf1\u5bfc\u7684NASH\u6a21\u578b\uff0c\u4e3b\u8981\u662f\u4ee5\u9ad8\u8102\u80aa\u9972\u6599\u52a0\u5316\u5b66\u836f\u7269\u6765\u8fdb\u884c\u9020\u6a21\uff0c\u5305\u62ec\u56db\u6c2f\u5316\u78b3\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u56db\u73af\u7d20\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3001\u4e59\u786b\u6c28\u9178\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\u3002 \u2462 \u7279\u6b8a\u54c1\u7cfb\u8102\u80aa\u809d\u52a8\u7269\u6a21\u578b\uff0c\u4e3b\u8981\u6709\u7626\u7d20\u7f3a\u4e4f\u548c\u62b5\u6297\u5c0f\u9f20\u6a21\u578b\u3001PTEN\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u6a21\u578b\u3002\u5176\u4e2d\uff0cMCD\u9972\u6599\u8bf1\u5bfc\u7684NASH\u6a21\u578b\u662f\u76ee\u524d\u56fd\u9645\u4e0a\u88ab\u5e7f\u6cdb\u8ba4\u53ef\u7684\u6a21\u578b\u3002 \u8be5\u6a21\u578b\u6700\u65e9\u7531Shinozuka\u63d0\u51fa\uff0c\u8d77\u521d\u662f\u7528\u4e8e\u63a2\u8ba8\u996e\u98df\u56e0\u7d20\u5bf9\u809d\u810f\u80bf\u7624\u5f62\u6210\u7684\u5f71\u54cd\uff0c\u540e\u6765\u53d1\u73b0\u5728\u77ed\u671f\u5185\u53ef\u4ee5\u5f15\u8d77\u8102\u80aa\u6027\u809d\u708e\u3002\u8be5\u6a21\u578b\u7684\u8102\u80aa\u6027\u809d\u708e\u53d1\u5c55\u901f\u5ea6\u5feb\uff0c\u5176\u75c5\u7406\u75c5\u53d8\u4e0e\u4eba\u7c7b\u7684NASH\u7c7b\u4f3c\uff0c\u56e0\u6b64\u6210\u4e3a\u8fd1\u5e74\u6765\u56fd\u5185\u5916\u5b66\u8005\u7814\u7a76NASH\u7684\u70ed\u70b9\u6a21\u578b\uff0c\u4f46\u672a\u89c1\u5173\u4e8e\u5728\u5927\u5c0f\u9f20\u4f53\u5185\u7528MCD\u9972\u6599\u8bf1\u5bfcNASH\u6a21\u578b\u5dee\u5f02\u6bd4\u8f83\u7684\u62a5\u9053\u3002 \u672c\u7814\u7a76\u65e8\u5728\u901a\u8fc7MCD\u9972\u6599\u5206\u522b\u5efa\u7acb\u5927\u3001\u5c0f\u9f20NASH\u6a21\u578b\uff0c\u6bd4\u8f83\u5176\u751f\u5316\u548c\u75c5\u7406\u6307\u6807\uff0c\u63a2\u8ba8\u4e24\u79cd\u52a8\u7269\u6a21\u578b\u7684\u5dee\u5f02\uff0c\u4e3aNASH\u7684\u57fa\u7840\u7814\u7a76\u548c\u9632\u6cbb\u836f\u7269\u7684\u5f00\u53d1\u63d0\u4f9b\u53ef\u9760\u7684\u52a8\u7269\u6a21\u578b\u3002 \u5b9e\u9a8c\u52a8\u7269\u4e0e\u65b9\u6848 \u5b9e\u9a8c\u52a8\u7269 SPF\u7ea7C57BL\/6\u96c4\u6027\u5c0f\u9f2018\u53ea\uff0c8~9\u5468\u9f84\uff0c\u4f53\u91cd\u4e3a22~25 g\uff1bSPF\u7ea7SD\u96c4\u6027\u5927\u9f2018\u53ea\uff0c8~9\u5468\u9f84\uff0c\u4f53\u91cd\u4e3a300~350g\u3002\u9972\u517b\u4e8e\u9075\u4e49\u533b\u5b66\u9662\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\uff0c\u5c4f\u969c\u73af\u5883\u52a8\u7269\u623f\u5ba4\u6e29\uff0822 \u00b11\uff09\u00b0 \uff0c\u76f8\u5bf9\u6e7f\u5ea630%~60%\uff0c12h\u5149\u7167\/12h\u9ed1\u6697\uff0c\u52a8\u7269\u81ea\u7531\u91c7\u98df\u548c\u996e\u6c34\u3002 \u5b9e\u9a8c\u8bd5\u5242 \u68c0\u6d4b\u8c37\u4e19\u8f6c\u6c28\u9176\uff08ALT\uff09\u3001\u8c37\u8349\u8f6c\u6c28\u9176\uff08AST\uff09\u3001\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u548c\u80c6\u56fa\u9187\uff08TC\uff09\u542b\u91cf\u7684\u8bd5\u5242\u76d2\uff0c\u5747\u8d2d\u81ea\u5fb7\u56fd\u7f57\u6c0f\u8bca\u65ad\u516c\u53f8\uff0c\u6309\u8bf4\u660e\u4e66\u548c\u6587\u732e\u62a5\u9053\u7684\u65b9\u6cd5\u8fdb\u884c\u68c0\u6d4b\u3002 \u52a8\u7269\u9972\u6599 \u86cb\u6c28\u9178\u80c6\u78b1\u7f3a\u4e4f\uff08MCD\uff09\u9972\u6599\u548c\u86cb\u6c28\u9178\u80c6\u78b1\u5145\u8db3\uff08MCS\uff09\u9972\u6599\uff0c\u6839\u636e\u9972\u6599\u751f\u4ea7\u516c\u53f8\u6280\u672f\u4eba\u5458\u7684\u6307\u5bfc\u8fdb\u884c\u9972\u517b\u3002 \u52a8\u7269\u5206\u7ec4 \u5c0618\u53eaC57BL\/6\u5c0f\u9f20\u548c18\u53eaSD\u5927\u9f20\u5206\u522b\u968f\u673a\u5206\u6210\u6b63\u5e38\u7ec4\uff08\u9972\u5582MCS\u9972\u6599\uff09\u548c\u6a21\u578b\u7ec4\uff08\u9972\u5582MCD\u9972\u6599\uff09\u3002\u6a21\u578b\u7ec4\u9700\u89811\u5468\u8fc7\u6e21\u6027\u9972\u6599\u7684\u5582\u517b\uff0c\u7b2c1 ~3\u5929\u5c06MCS\u548c MCD\u9972\u6599\u63092:1\u6df7\u5408\u540e\u5582\u517b\uff0c\u7b2c4 ~5\u5929\u63091:1\u6df7\u5408\u5582\u517b\uff0c\u7b2c6-7\u5929\u63091:2\u6df7\u5408\u5582\u517b\uff0c1\u5468\u540e\u5b8c\u5168\u6295\u5582MCD\u9972\u6599\u3002\u8fc7\u6e21\u6027\u9972\u517b\u540e\u7684\u7b2c3\u30015\u30018\u5468\u5728\u5404\u7ec4\u4e2d\u5206\u522b\u968f\u673a\u9009\u53d66\u53ea\u52a8\u7269\u6837\u672c\uff0c\u8fdb\u884c\u809d\u529f\u80fd\u751f\u5316\u6307\u6807\u548c\u809d\u810f\u75c5\u7406\u7684\u68c0\u6d4b\u3002\u4ece\u8fc7\u6e21\u9972\u5582\u5f00\u59cb\u4e14\u6bcf\u5468\u79f0\u91cf\u52a8\u7269\u4f53\u8d28\u91cf\uff08g\uff09\u5e76\u8bb0\u5f55\u3002 \u5b9e\u9a8c\u7ed3\u679c \u4f53\u8d28\u91cf\u53d8\u5316 \u6b63\u5e38\u5bf9\u7167\u7ec4\u5b9e\u9a8c\u52a8\u7269\u7684\u4f53\u8d28\u91cf\u6301\u7eed\u589e\u957f\uff0c\u6a21\u578b\u7ec4\u5b9e\u9a8c\u52a8\u7269\u4f53\u8d28\u91cf\u9010\u6e10\u51cf\u8f7b\uff1b\u4ece\u7b2c 3\u5468\u5f00\u59cb\uff0c\u76f8\u6bd4\u4e8e\u6b63\u5e38\u7ec4\uff0c\u6a21\u578b\u7ec4\u7684\u5b9e\u9a8c\u52a8\u7269\u4f53\u8d28\u91cf\u90fd\u663e\u8457\u964d\u4f4e\u3002 \u52a8\u7269\u8840\u6e05\u4e2dALT\u3001AST\u3001TC\u548cTG\u7684\u542b\u91cf \u4ece\u7b2c3\u5468\u5f00\u59cb\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u9176AST\u548cALT\u6c34\u5e73\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\uff0c\u5747\u5df2\u663e\u8457\u5347\u9ad8\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5927\u9f20\u6a21\u578b\u7ec4\u5728\u68c0\u6d4b\u76843\u4e2a\u65f6\u95f4\u70b9\uff0c\u809d\u9176AST\u6c34\u5e73\u65e0\u663e\u8457\u53d8\u5316\uff0c\u800cALT\u6c34\u5e73\u4ece\u7b2c3\u5468\u5f00\u59cb\u663e\u8457\u5347\u9ad8\u3002\u5728\u68c0\u6d4b\u7684\u9020\u6a21\u540e\u7b2c3\u5468\u30015\u5468\u30018 \u5468\uff0c\u5927\u3001\u5c0f\u9f20\u8840\u6e05\u4e2dTG\u548cTC\u542b\u91cf\u5747\u663e\u8457\u964d\u4f4e\u3002 \u809d\u7ec4\u7ec7HE\u67d3\u8272 \u6b63\u5e38\u5bf9\u7167\u7ec4\u809d\u5c0f\u53f6\u7ed3\u6784\u6e05\u6670\u3001\u5b8c\u6574\uff0c\u809d\u7ec6\u80de\u4ee5\u4e2d\u592e\u9759\u8109\u4e3a\u4e2d\u5fc3\uff0c\u5448\u653e\u5c04\u72b6\u6392 \u5217,\u65e0\u809d\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u6216\u708e\u75c7\u7ec6\u80de\u6d78\u6da6\uff08\u89c1\u56fe1A\u3001C\uff09\u3002MCD\u9972\u6599\u9972\u55828\u5468\u540e\uff0c\u6a21\u578b\u7ec4\u7684\u5927\u9f20\u809d\u7ec4\u7ec7\u5c0f\u53f6\u7ed3\u6784\u5df2\u88ab\u7834\u574f\uff0c\u5927\u6ce1\u6027\u6c14\u7403\u6837\u53d8\u7ec6\u80de\u5360\u4e86\u603b\u7ec6\u80de\u76842\/3\u4ee5\u4e0a\uff0c\u4ee5\u809d\u5c0f\u53f6\u5468\u8fb9\u8102\u80aa\u53d8\u6027\u6700\u4e3a\u4e25\u91cd\uff0c \u5c40\u90e8\u53ef\u89c1\u5927\u6ce1\u6027\u6c14\u7403\u6837\u53d8\u548c\u4ee5\u5355\u4e2a\u6838\u7ec6\u80de\u6d78\u6da6\u4e3a\u4e3b\u708e\u75c7\u53cd\u5e94\uff08\u89c1\u56fe1B\uff09\u30028\u5468\u65f6\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u5149\u955c\u4e0b\u89c1\u809d\u5c0f\u53f6\u7ed3\u6784\u7d0a\u4e71\uff0c\u7ec6\u80de\u51fa\u73b0\u4e25\u91cd\u7684\u8102\u80aa\u53d8 \u6027\uff0c\u4e2d\u592e\u9759\u8109\u5468\u56f4\u51fa\u73b0\u4e25\u91cd\u3001\u4ee5\u6d78\u6da6\u4e3a\u4e3b\u7684\u5c40\u7076\u574f \u6b7b\u6027\u708e\u75c7\uff08\u89c1\u56fe1D\uff09\u3002\u5177\u4f53NAFLD\u6d3b\u52a8\u5ea6\u79ef\u5206\u89c1\u88683\uff0cSD\u5927\u9f20\u548cC57BL\/6\u5c0f\u9f20\u7efc\u5408\u8bc4\u5206\u5747\u8868\u73b0\u4e3a\u6a21\u578b\u7ec4\u4e0e\u6b63\u5e38\u7ec4\u4e4b\u95f4\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P&lt; 0. 05\uff09\u3002 \u5b9e\u9a8c\u8ba8\u8bba MCD\u9972\u6599\u8bf1\u5bfc\u7684NASH\u6a21\u578b\u7684\u4e3b\u8981\u53d1\u75c5\u673a\u5236\u662f\u7531\u4e8e\u9972\u6599\u7f3a\u4e4f\u80c6\u78b1\u800c\u5f15\u8d77\u673a\u4f53\u5375\u78f7\u8102\u5408\u6210\u4e0d\u8db3\u3002\u86cb\u6c28\u9178\u4e3a\u5408\u6210\u8f7d\u8102\u86cb\u767d\u6240\u5fc5\u9700\u7684\u6c28\u57fa\u9178\uff0c\u7f3a\u4e4f \u9178\u4f1a\u5bfc\u81f4\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\u5408\u6210\u51cf\u5c11\uff0c\u56e0\u6b64\u65e0\u6cd5 \u5c06\u4e09\u9170\u7518\u6cb9\u8fd0\u51fa\u809d\u5916\u800c\u7d2f\u79ef\u5f62\u6210\u8102\u80aa\u809d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7f3a\u4e4f\u80c6\u78b1\u8fd8\u4f1a\u5f15\u8d77\u809d\u810f\u7ebf\u7c92\u4f53\u5185\u90e8\u6d3b\u6027\u6c27\u589e\u52a0\uff0c\u6700\u7ec8\u5bfc\u81f4\u6c27\u5e94\u6fc0\u589e\u52a0\u800c\u809d\u810f\u53d1\u751f\u635f\u4f24\u3002\u6c27\u5e94\u6fc0\u4e0d\u4f46\u5bfc\u81f4\u7ec6\u80de\u591a\u79cd\u529f\u80fd\u548c\u7ed3\u6784\u635f\u4f24\uff0c\u800c\u4e14\u6d3b\u5316TNF\u03b1\u53ca\u5176\u4ed6\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u3002 \u8be5\u6a21\u578b\u81ea1978\u5e74Shinozuka\u63d0\u51fa\u4ee5\u6765\uff0c\u88ab\u56fd\u5185\u5916\u7684\u5b66\u8005\u5e7f\u6cdb\u5e94\u7528\u4e8e\u836f\u7269\u7b5b\u9009\uff0c\u4f46\u662f\u7f3a\u5c11\u6587\u732e\u5bf9\u8be5\u6a21\u578b\u5728C57BL\/6\u5c0f\u9f20\u548cSD\u5927\u9f20\u7684\u7cfb\u7edf\u6027\u62a5\u9053\u3002\u4e8e\u662f\u672c\u5b9e\u9a8c\u9972\u5582MCD\u9972\u6599\u5efa\u7acb\u5927\u3001\u5c0f\u9f20NASH\u6a21\u578b\uff0c\u5bf9\u5176\u8840\u6db2\u7684\u751f\u5316\u6307\u6807\u548c\u809d\u810f\u7684\u75c5\u7406\u6307\u6807\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u65e8\u5728\u63a2\u8ba8\u4e24\u79cd\u52a8\u7269\u6a21\u578b\u7684\u751f\u5316\u548c\u75c5\u7406\u5dee\u5f02\uff0c\u4ee5\u9009\u62e9\u7406\u60f3\u7684\u52a8\u7269\u6a21\u578b\u3002 \u672c\u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\uff0c\u5728\u809d\u635f\u4f24\u6307\u6570\u65b9\u9762\uff0c\u9972\u5582MCD\u9972\u6599\u7684\u7b2c3\u5468\u5f00\u59cb\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u7684\u809d\u9176AST\u3001 ALT\u6c34\u5e73\u4e0e\u6b63\u5e38\u7ec4\u76f8\u6bd4\u5df2\u7ecf\u663e\u8457\u5347\u9ad8\uff0c\u4f46\u6a21\u578b\u5927\u9f20 AST\u6c34\u5e73\u4ece\u5b9e\u9a8c\u5f00\u59cb\u81f3\u7ed3\u675f\u4ecd\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u800cAST\u548cALT\u7684\u6c34\u5e73\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u901a\u5e38\u4f5c\u4e3a\u809d\u810f\u529f\u80fd\u8bc4\u4ef7\u91cd\u8981\u6307\u6807\uff0c\u53cd\u6620\u8102\u80aa\u809d\u7684\u65e9\u671f\u635f\u5bb3\uff0c\u56e0\u6b64\u8868\u660eC57BL\/6\u5c0f\u9f20\u5bf9MCD\u9972\u6599\u7684\u53cd\u5e94\u5728\u65e9\u671f\u6bd4SD\u5927\u9f20\u66f4\u654f\u611f \uff0c\u66f4\u5bb9\u6613\u5f15\u8d77\u809d\u635f\u4f24\u809d \u3002 \u800c\u4e14\u809d\u7ec4\u7ec7\u75c5\u7406\u7ed3\u679c\u663e\u793a\uff0c\u9972\u5582MCD\u9972\u65998\u5468\uff0c\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u6bd4\u5927\u9f20\u51fa\u73b0\u7684\u8102\u80aa\u53d8\u6027\u66f4\u4e25\u91cd\uff0c\u5c0f\u533a\u57df\u51fa\u73b0\u5c0f\u6ce1\u4e3a\u4e3b\u7684\u7ec6\u80de\u6c14\u7403\u6837\u53d8\u53ca\u8f7b\u5fae\u7684\u708e\u75c7\u53cd\u5e94\uff1b\u540c\u65f6\u901a\u8fc7\u809d\u7ec4\u7ec7\u75c5\u4f8b\u8bc4\u5206\u7ed3\u679c\u8868\u660e8\u5468\u540e\u6a21\u578b\u7ec4\u5c0f\u9f20\u809d\u7ec4\u7ec7\u708e\u75c7\u53cd\u5e94\u53ca\u8102\u80aa\u53d8\u6027\u7b49\u75c5\u7406\u7279\u5f81\u7684\u5f97\u5206\u660e\u663e\u9ad8\u4e8e\u5927\u9f20\u3002\u53e6\u5916\uff0c\u5c0f\u9f20\u5177\u6709\u91c7\u98df\u91cf\u5c11\u3001\u6210\u672c\u4f4e\u53ca\u64cd\u4f5c\u65b9\u4fbf\u7b49\u4f18\u70b9\u3002\u56e0\u6b64\uff0c\u7efc\u5408\u751f\u5316\u6307\u6807\u53ca\u75c5\u7406\u7279\u5f81\u7b49\u56e0\u7d20\uff0cMCD\u9972\u6599\u8bf1\u5bfc\u7684C57BL\/6\u5c0f\u9f20\u6a21\u578b\u6bd4SD\u5927\u9f20\u6a21\u578b\u66f4\u9002\u7528\u4e8e\u8fdb\u4e00\u6b65\u7814\u7a76NASH. \u672c\u6587\u4f5c\u8005\uff1a\u5d14\u56fd\u796f\/\u4f59\u6c49\u6fe0\/\u9ec4\u5929\u517b\/\u738b\u6587\/\u5f90\u4e49\u7965\/\u7a0b\u81ea\u521a\/\u5434\u5f69\u71d5\/\u674e\u94ed\u6e90\uff0c\u9075\u4e49\u533b\u5b66\u9662<\/p>\n","protected":false},"author":3,"featured_media":4822,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[10],"tags":[370],"_links":{"self":[{"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/posts\/4819"}],"collection":[{"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/comments?post=4819"}],"version-history":[{"count":0,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/posts\/4819\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/media\/4822"}],"wp:attachment":[{"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/media?parent=4819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/categories?post=4819"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.ychljhotel.com\/en\/wp-json\/wp\/v2\/tags?post=4819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<a href="http://www.ychljhotel.com/">&#x4E9A;&#x6D32;&#x5077;&#x81EA;&#x62CD;&#x9875;&#x2C;&#x4E9A;&#x6D32;&#x65E5;&#x97E9;&#x5C0F;&#x8BF4;&#x81EA;&#x62CD;&#x2C;&#x81EA;&#x62CD;&#x5077;&#x533A;&#x4E9A;&#x6D32;&#x56FD;&#x5185;&#x81EA;&#x62CD;&#x871C;&#x81C0;&#x2C;&#x6B27;&#x7F8E;&#x53E6;&#x7C7B;&#x4E9A;&#x6D32;&#x5361;&#x901A;&#x81EA;&#x62CD;</a>

(function(){
    var bp = document.createElement('script');
    var curProtocol = window.location.protocol.split(':')[0];
    if (curProtocol === 'https') {
        bp.src = 'https://zz.bdstatic.com/linksubmit/push.js';
    }
    else {
        bp.src = 'http://push.zhanzhang.baidu.com/push.js';
    }
    var s = document.getElementsByTagName("script")[0];
    s.parentNode.insertBefore(bp, s);
})();

</body>