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\u4f5c\u8005\uff1aTony Y. Wang\u3001Piero Portincasa\u7b49<\/span><\/em><\/p>\n

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Cludin 2\uff08Cldn2\uff09\u662f\u4e00\u79cd\u7ec6\u80de\u65c1\u901a\u9053\u5f62\u6210\u86cb\u767d\uff0c\u5728\u809d\u7ec6\u80de\u548c\u80c6\u7ba1\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u3002Matsumoto\u7814\u7a76\u53d1\u73b0Cldn2\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684\u80c6\u6c41\u6d41\u901f\u4e0e\u91ce\u751f\u578b\u5c0f\u9f20\u76f8\u6bd4\u964d\u4f4e\u4e8650%\uff0c\u8fd9\u662f\u7531\u4e8e\u809d\u80c6\u7cfb\u7edf\u7684\u6c34\u6e17\u900f\u6027\u964d\u4f4e\u6240\u81f4\uff0c\u4ece\u800c\u663e\u8457\u589e\u52a0\u80c6\u6c41\u4e2d\u7684\u603b\u8102\u8d28\u6d53\u5ea6\u30024\u5468\u540e\uff0cCldn2\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u4ea7\u751f\u4e86\u80c6\u7ed3\u77f3\uff0c\u800c\u91ce\u751f\u578b\u5c0f\u9f20\u5e76\u6ca1\u6709\u51fa\u73b0\u7ed3\u77f3\uff0c\u8fd9\u8868\u660eCldn2\u5bf9\u80c6\u6c41\u5f62\u6210\u548c\u80c6\u6c41\u8102\u8d28\u7a33\u6001\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u5728ABCG5\u548cABCG8\u4e24\u79cd\u57fa\u56e0\u5355\u72ec\u7f3a\u5931\u6216\u90fd\u7f3a\u5931\u7684\u5c0f\u9f20\u809d\u810f\u4e2d\u80c6\u56fa\u9187\u5206\u6ccc\u663e\u8457\u964d\u4f4e\uff0c\u4f46\u6ca1\u6709\u5b8c\u5168\u6d88\u9664\uff0c\u8fd9\u8868\u660e\u5b58\u5728\u4e00\u79cdABCG5\/G8\u975e\u4f9d\u8d56\u901a\u8def\u53ef\u8c03\u8282\u4eba\u4f53\u548c\u5c0f\u9f20\u7684\u80c6\u6c41\u80c6\u56fa\u9187\u5206\u6ccc\u3002<\/p>\n

Wang\u7b49\u7814\u7a76\u8005\u6307\u51fa\uff0c\u5728\u6210\u77f3\u72b6\u6001\u4e0b\uff0cABCG5\/G8\u975e\u4f9d\u8d56\u901a\u8def\u80c6\u56fa\u9187\u8f93\u51fa\u5360\u603b\u91cf\u768430%\u81f340%\uff0c\u5728\u9ad8\u80c6\u56fa\u9187\u996e\u98df\u4e2d\u8c03\u8282\u673a\u4f53\u80c6\u56fa\u9187\u5206\u6ccc\u4e0a\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5728ABCG5\/G8\u7f3a\u5931\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u9014\u5f84\u53c2\u4e0e\u4e86\u80c6\u56fa\u9187\u7684\u5206\u6ccc\u548c\u80c6\u7ed3\u77f3\u5f62\u6210\u3002\u4e0eABCG5\/G8\u4e0d\u540c\u7684\u662f\uff0c\u8fd9\u79cd\u901a\u8def\u9014\u5f84\u5e76\u4e0d\u662f\u7531LXR\u901a\u8fc7\u5176\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u7684\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\u4e86ABCG5\/G8\u4f9d\u8d56\u6027\u548cABCG5\/G8\u975e\u4f9d\u8d56\u6027\u901a\u8def\u5728\u809d\u810f\u80c6\u56fa\u9187\u5206\u6ccc\u548c\u80c6\u56ca\u7ed3\u77f3\u5f62\u6210\u4e2d\u90fd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u9053\u80c6\u56ca\u6536\u7f29\u7d20\uff08CCK\uff09\u7684\u5206\u6ccc\u548c\u80c6\u56ca\u6392\u7a7a\u53d7\u9ad8\u8102\u996e\u98df\u7684\u7834\u574f\uff0c\u4f46\u8179\u8154\u75be\u75c5\u5bf9\u80c6\u7ed3\u77f3\u5f62\u6210\u7684\u5f71\u54cd\u76ee\u524d\u5f88\u5c11\u6709\u7814\u7a76\u3002Wang\u7b49\u4eba\u5efa\u7acbCCK\u7f3a\u4e4f\u5c0f\u9f20\u6a21\u578b\u6765\u7814\u7a76\u8179\u8154\u75be\u75c5\u5bf9\u80c6\u6c41\u5206\u6ccc\u7684\u5f71\u54cd\uff0c\u53d1\u73b0CCK\u57fa\u56e0\u6572\u9664\u540e\u5c0f\u9f20\u8868\u73b0\u80c6\u56ca\u6392\u7a7a\u53d7\u635f\uff0c\u5c0f\u80a0\u8f6c\u8fd0\u65f6\u95f4\u51cf\u5c11\uff0c\u80a0\u9053\u80c6\u56fa\u9187\u5438\u6536\u589e\u52a0\uff0c\u8fc7\u91cf\u7684\u80a0\u9053\u6e90\u6027\u80c6\u56fa\u9187\u5bfc\u81f4\u80c6\u6c41\u9ad8\u5206\u6ccc\uff0c\u4ece\u800c\u5f15\u8d77\u80c6\u56fa\u9187\u7ed3\u6676\u548c\u80c6\u77f3\u5f62\u6210\u3002\u6b64\u5916\uff0c\u6709\u7814\u7a76\u53d1\u73b0\u5f3a\u6548CCK-1\u53d7\u4f53\u62ee\u6297\u5242Devaxipide\u901a\u8fc7\u635f\u5bb3\u5c0f\u9f20\u80c6\u56ca\u6392\u7a7a\u529f\u80fd\uff0c\u6270\u4e71\u80c6\u56fa\u9187\u4ee3\u8c22\u548c\u589e\u5f3a\u80a0\u9053\u80c6\u56fa\u9187\u5438\u6536\uff0c\u589e\u52a0\u4e86\u80c6\u7ed3\u77f3\u5f62\u6210\u7684\u98ce\u9669\u3002\u4e0a\u8ff0\u5b9e\u9a8c\u4e3a\u7814\u7a76\u8179\u8154\u75be\u75c5\u60a3\u8005\u80c6\u7ed3\u77f3\u7684\u53d1\u75c5\u673a\u5236\u63d0\u4f9b\u4e86\u91cd\u8981\u4f9d\u636e\u3002<\/p>\n

\u80c6\u6c41\u4e2d\u53ef\u80fd\u540c\u65f6\u542b\u6709\u4fc3\u6838\u56e0\u5b50\u548c\u6297\u6838\u56e0\u5b50\uff0c\u5176\u542b\u91cf\u7684\u4e0d\u5e73\u8861\u53ef\u80fd\u5bfc\u81f4\u80c6\u56fa\u9187\u5feb\u901f\u7ed3\u6676\u4ece\u800c\u5f62\u6210\u7ed3\u77f3\uff0c\u4f46\u8fd9\u4e00\u8bf4\u6cd5\u4ecd\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u8bc1\u5b9e\u3002\u7c98\u86cb\u767d\u662f\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684\u4fc3\u8fdb\u80c6\u56fa\u9187\u7ed3\u6676\u6210\u77f3\u7684\u86cb\u767d\u5206\u5b50\uff0c\u8fd8\u6709\u8bb8\u591a\u5176\u4ed6\u86cb\u767d\u4e5f\u88ab\u8ba4\u4e3a\u662f\u5f71\u54cd\u80c6\u6c41\u4e2d\u80c6\u56fa\u9187\u7ed3\u6676\u7684\u4fc3\u6838\u56e0\u5b50\u6216\u6297\u6838\u56e0\u5b50\uff0c\u4f46\u5b83\u4eec\u4f5c\u7528\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n

Niemann Pick C2\uff08NPC2\uff09\u662f\u4e00\u79cd\u53ef\u6eb6\u6027\u6eb6\u9176\u4f53\u86cb\u767d\uff0c\u901a\u8fc7\u6fc0\u6d3bABCG5\/G8\u4ecb\u5bfc\u7684\u80c6\u56fa\u9187\u8f6c\u8fd0\u901a\u8def\u6765\u8c03\u8282\u809d\u810f\u80c6\u56fa\u9187\u5206\u6ccc\uff0c\u5b83\u4fc3\u8fdb\u8f6c\u57fa\u56e0\u5c0f\u9f20\uff08\u4ebaNPC2\u57fa\u56e0\uff09\u7684\u80c6\u56fa\u9187\u7ed3\u6676\u548c\u80c6\u77f3\u5f62\u6210\u3002\u76f8\u6bd4\u800c\u8a00\uff0cNPC2\u57fa\u56e0\u7f3a\u4e4f\u7684\u5c0f\u9f20\u5728\u9ad8\u80c6\u56fa\u9187\u9972\u6599\u9972\u55822\u5468\u540e\u809d\u810f\u80c6\u56fa\u9187\u5206\u6ccc\u548c\u80c6\u77f3\u7387\u51cf\u5c11\u3002\u4e0a\u8ff0\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b\u80c6\u6c41\u86cb\u767d\u53ef\u80fd\u901a\u8fc7\u80c6\u6c41\u4e2d\u7684\u6db2\u6676\u9014\u5f84\u6765\u8c03\u8282\u80c6\u56fa\u9187\u7684\u7ed3\u6676\u4ee5\u5bfc\u81f4\u80c6\u7ed3\u77f3\u53d1\u751f\u3002<\/p>\n

\u80a0\u9053\u80c6\u56fa\u9187\u7684\u9ad8\u6548\u7387\u5438\u6536\u548c\u9ad8\u80c6\u56fa\u9187\u996e\u98df\uff08\u897f\u65b9\u996e\u98df\u6a21\u5f0f\uff09\u662f\u5c0f\u9f20\u7684\u4e24\u4e2a\u81f4\u77f3\u56e0\u7d20\u3002\u6df1\u5165\u7814\u7a76\u53d1\u73b0\uff0c\u6709\u5f88\u591a\u56e0\u7d20\u90fd\u53ef\u4ee5\u5728\u80a0\u9053\u80c6\u56fa\u9187\u5438\u6536\u3001\u8fd0\u9001\u81f4\u809d\u810f\u5e76\u5206\u6ccc\u4e8e\u80c6\u6c41\u4e2d\u7684\u9014\u5f84\u4e0a\u5f71\u54cd\u80c6\u56fa\u9187\u7684\u7ed3\u6676\u800c\u5bfc\u81f4\u80c6\u7ed3\u77f3\u7684\u5f62\u6210\uff0c\u5982\u80c6\u56fa\u9187\u916f\u5316\u3001\u80a0\u7ec6\u80de\u5185\u8102\u8d28\u8f6c\u8fd0\u3001\u4e73\u7cdc\u5fae\u7c92\u7684\u805a\u96c6\u7b49\u3002\u6b64\u5916\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u548c\u514d\u75ab\u7cfb\u7edf\u5bf9\u80c6\u7ed3\u77f3\u5f62\u6210\u4e5f\u6709\u91cd\u8981\u7684\u5f71\u54cd\uff0c\u4f46\u4ecd\u5f85\u8fdb\u4e00\u6b65\u6df1\u5165\u7814\u7a76\u3002<\/p>\n

\u56e0\u6b64\uff0c\u90a3\u4e9b\u5f71\u54cd\u809d\u7ec6\u80de\u8f6c\u8fd0\u548c\u80c6\u6c41\u5206\u6ccc\u80c6\u56fa\u9187\u3001\u78f7\u8102\u548c\u80c6\u6c41\u9178\u7684\u56e0\u7d20\u90fd\u53ef\u4ee5\u901a\u8fc7\u5f15\u8d77\u80c6\u56fa\u9187\u9ad8\u5206\u6ccc\u548c\u80c6\u56fa\u9187\u8fc7\u9971\u548c\u80c6\u6c41\u6765\u4fc3\u8fdb\u80c6\u7ed3\u77f3\u7684\u5f62\u6210\u3002\u4e00\u4e9b\u53d7\u4f53\uff0c\u5982liver X receptor (LXR)\u3001farnesoid X receptor(FXR)\u3001pregnane X receptor (PXR)\u3001constitutive androstane receptor (CAR)\u3001 ERa\u7b49\u53ef\u4ee5\u901a\u8fc7\u809d\u810f\u8102\u8d28\u4ee3\u8c22\u7684\u9014\u5f84\u6765\u5f71\u54cd\u80c6\u7ed3\u77f3\u7684\u5f62\u6210\u3002\u8fd8\u6709\uff0c\u5bf9\u809d\u810f\u80f0\u5c9b\u7d20\u53d7\u4f53\u7684\u7834\u574f\u4e5f\u80fd\u63d0\u9ad8\u5c0f\u9f20\u80c6\u7ed3\u77f3\u7684\u53d1\u75c5\u7387\uff0c\u8fd9\u79cd\u7834\u574f\u53ef\u4ee5\u964d\u4f4e\u80c6\u56fa\u91877a\u7f9f\u5316\u9176\u7684\u6d3b\u6027\u5e76\u5f71\u54cd\u80c6\u6c41\u9178\u7684\u5408\u6210\uff0c\u4f46\u80f0\u5c9b\u7d20\u62b5\u6297\u5728\u80c6\u7ed3\u77f3\u5f62\u6210\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u4e5f\u5c1a\u4e0d\u660e\u786e\u3002<\/p>\n

\u7ed3\u8bba<\/strong><\/p>\n

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\u672c\u6587\u6765\u6e90\uff1aMouse Models Of Gallstone Disease\uff1bTony Y. Wang\/Piero Portincasa\u8457<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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