{"id":5716,"date":"2021-07-09T16:31:31","date_gmt":"2021-07-09T08:31:31","guid":{"rendered":"http:\/\/www.ychljhotel.com\/?p=5716"},"modified":"2022-10-13T16:29:57","modified_gmt":"2022-10-13T08:29:57","slug":"den%e9%ab%98%e8%83%86%e5%9b%ba%e9%86%87%e9%a5%ae%e9%a3%9f%e4%bf%83%e8%bf%9bnash%e5%b0%8f%e9%bc%a0%e5%90%91hcc%e5%8f%91%e5%b1%95","status":"publish","type":"post","link":"http:\/\/www.ychljhotel.com\/en\/5716\/","title":{"rendered":"DEN+\u9ad8\u80c6\u56fa\u9187\u996e\u98df\u4fc3\u8fdbNASH\u5c0f\u9f20\u5411HCC\u53d1\u5c55"},"content":{"rendered":"<p>HCC\uff08\u809d\u7ec6\u80de\u764c\uff09\u662f\u6700\u5e38\u89c1\u7684\u809d\u764c\u7c7b\u578b\uff0c\u5176\u4e2d\u6709\u5f88\u5927\u4e00\u90e8\u5206\u662f\u7531NASH\uff08\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff09\u53d1\u5c55\u800c\u6765\u3002\u81b3\u98df\u80c6\u56fa\u9187\u53ef\u901a\u8fc7\u5408\u6210BA(\u80c6\u6c41\u9178)\u4fc3\u8fdbHCC\u53d1\u751f\u3002\u7ebf\u7c92\u4f53\u80c6\u56fa\u9187\u4e3b\u8981\u901a\u8fc7STARD1\uff08\u753e\u4f53\u5408\u6210\u6025\u6027\u8c03\u8282\u86cb\u767d1\uff09\u8fdb\u884c\u8c03\u63a7\uff0c\u4f46\u5176\u5bf9HCC\u53d1\u5c55\u7684\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u53d1\u73b0\u4e86STARD1\u523a\u6fc0\u80c6\u6c41\u9178\u4ea7\u751f\uff0c\u4ece\u800c\u4fc3\u8fdbNASH\u5411HCC\u53d1\u5c55\u3002\u76f8\u5173\u6587\u732e\u53d1\u8868\u4e8e\u300a<em>Journal of Hepatology<\/em>\u300b\u3002<\/p>\n<p><strong>1\u3001NASH\u53d1\u5c55\u800c\u6765\u7684HCC\u60a3\u8005STARD1\u8868\u8fbe\u589e\u52a0\uff0cBA\u6c34\u5e73\u5f02\u5e38<\/strong><\/p>\n<p>\u809d\u810f\u4e2dSTARD1\u57fa\u7840\u8868\u8fbe\u8f83\u4f4e\uff0c\u4f46\u5728NASH\u60a3\u8005\u4e2dSTARD1\u8868\u8fbe\u4e0a\u8c03\uff0c\u800c\u5728\u5355\u7eaf\u8102\u80aa\u53d8\u6027\u7684\u53d7\u8bd5\u8005\u4e2d\u65e0\u53d8\u5316\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cNASH\u9a71\u52a8\u7684HCC\u60a3\u8005\u809d\u810f\u4e2dSTARD1\u57fa\u56e0\u8f6c\u5f55\u6c34\u5e73\u548cSTARD1\u86cb\u767d\u6c34\u5e73\u589e\u52a0\u3002\u809d\u5207\u7247\u514d\u75ab\u7ec4\u5316\u663e\u793aSTARD1\u67d3\u8272\u589e\u5f3a\uff0c\u4e14\u809d\u810f\u6e38\u79bb\u80c6\u56fa\u9187\u6c34\u5e73\u5347\u9ad8\u3002\u540c\u65f6HCC\u60a3\u8005\u809d\u810f\u603bBA\u6c34\u5e73\u589e\u52a02\u500d\uff0c\u8fd9\u4e0eCYP7A1\u3001CYP8B1\u3001CYP27A1\u3001CYP7B1\u3001CYP7A1\u3001CYP27A1\u8868\u8fbe\u589e\u52a0\u4e00\u81f4\uff0c\u8868\u660eBA\u5408\u6210\u7684\u66ff\u4ee3\u9014\u5f84\u88ab\u6fc0\u6d3b\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-5717 aligncenter\" src=\"http:\/\/www.ychljhotel.com\/wp-content\/uploads\/2021\/07\/640.jpg\" alt=\"\" width=\"650\" height=\"344\" srcset=\"http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2021\/07\/640.jpg 650w, http:\/\/www.ychljhotel.com\/en\/wp-content\/uploads\/2021\/07\/640-500x265.jpg 500w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt; 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color: #808080;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p><span style=\"font-size: 10pt; color: #808080;\">Laura Conde de la Rosa, et al. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. <em>Journal of Hepatology<\/em>.2021.https:\/\/doi.org\/10.1016\/j.jhep.2021.01.028.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HCC\uff08\u809d\u7ec6\u80de\u764c\uff09\u662f\u6700\u5e38\u89c1\u7684\u809d\u764c\u7c7b\u578b\uff0c\u5176\u4e2d\u6709\u5f88\u5927\u4e00\u90e8\u5206\u662f\u7531NASH\uff08\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff09\u53d1\u5c55\u800c\u6765\u3002\u81b3\u98df\u80c6\u56fa\u9187\u53ef\u901a\u8fc7\u5408\u6210BA(\u80c6\u6c41\u9178)\u4fc3\u8fdbHCC\u53d1\u751f\u3002\u7ebf\u7c92\u4f53\u80c6\u56fa\u9187\u4e3b\u8981\u901a\u8fc7STARD1\uff08\u753e\u4f53\u5408\u6210\u6025\u6027\u8c03\u8282\u86cb\u767d1\uff09\u8fdb\u884c\u8c03\u63a7\uff0c\u4f46\u5176\u5bf9HCC\u53d1\u5c55\u7684\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u53d1\u73b0\u4e86STARD1\u523a\u6fc0\u80c6\u6c41\u9178\u4ea7\u751f\uff0c\u4ece\u800c\u4fc3\u8fdbNASH\u5411HCC\u53d1\u5c55\u3002\u76f8\u5173\u6587\u732e\u53d1\u8868\u4e8e\u300aJournal 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