{"id":5904,"date":"2021-07-26T14:45:53","date_gmt":"2021-07-26T06:45:53","guid":{"rendered":"http:\/\/www.ychljhotel.com\/?p=5904"},"modified":"2021-07-26T14:51:58","modified_gmt":"2021-07-26T06:51:58","slug":"%e8%a5%bf%e6%96%b9%e9%a5%ae%e9%a3%9f%e6%8d%9f%e5%ae%b3%e5%b0%8f%e9%bc%a0%e8%82%a0%e9%81%93%e5%85%8d%e7%96%ab%e7%bb%86%e8%83%9e%e5%8a%9f%e8%83%bd%e7%9a%84%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"http:\/\/www.ychljhotel.com\/en\/5904\/","title":{"rendered":"\u897f\u65b9\u996e\u98df\u635f\u5bb3\u5c0f\u9f20\u80a0\u9053\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u7684\u7814\u7a76"},"content":{"rendered":"<p>\u7531\u514b\u5229\u592b\u5170\u8bca\u6240\u7684\u533b\u5b66\u535a\u58ebThaddeus 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style=\"font-size: 10pt; color: #808080;\">\u539f\u6587\u68c0\u7d22\uff1aWestern diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation, <em>Cell Host &amp; Microbe<\/em> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7531\u514b\u5229\u592b\u5170\u8bca\u6240\u7684\u533b\u5b66\u535a\u58ebThaddeus Stpenbeck\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u9ad8\u8102\u80aa\u548c\u9ad8\u7cd6\u7684\u996e\u98df\u4e0e\u5c0f\u9f20\u80a0\u9053\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u53d7\u635f\u6709\u5173\u3002\u53d1\u8868\u5728\u300a\u7ec6\u80de\u5bbf\u4e3b\u4e0e\u5fae\u751f\u7269\u300b(Cell Host &amp; Microbe)\u6742\u5fd7\u4e0a\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u4e3a\u80a5\u80d6\u548c\u75be\u75c5\u9a71\u52a8\u7684\u80a0\u9053\u708e\u75c7\u4e4b\u95f4\u7684\u8054\u7cfb\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\uff0c\u5e76\u5bf9\u5f00\u53d1\u6cbb\u7597\u60a3\u8005\u708e\u75c7\u6027\u80a0\u75c5(IBD)\u7684\u9776\u70b9\u5177\u6709\u610f\u4e49\u3002 \u7814\u7a76\u4eba\u5458\u5229\u7528900\u591a\u540d\u60a3\u8005\u7684\u6570\u636e\u53d1\u73b0\uff0c\u5728\u514b\u7f57\u6069\u75c5\u548c\u975eIBD\u60a3\u8005\u4e2d\uff0c\u4f53\u91cd\u6307\u6570\u5347\u9ad8\u4e0e\u5f02\u5e38\u7684Paneth\u7ec6\u80de\u6709\u5173\u3002 Paneth\u7ec6\u80de\u662f\u4e00\u79cd\u5728\u80a0\u9053\u4e2d\u53d1\u73b0\u7684\u6297\u708e\u514d\u75ab\u7ec6\u80de\uff0c\u6709\u52a9\u4e8e\u9632\u6b62\u5fae\u751f\u7269\u5931\u8861\u548c\u611f\u67d3\u6027\u75c5\u539f\u4f53\u3002\u8fd9\u4e9b\u7ec6\u80de\u7684\u529f\u80fd\u969c\u788d\u662f\u7531\u57fa\u56e0\u7a81\u53d8\u548c\u73af\u5883\u56e0\u7d20\u5171\u540c\u9a71\u52a8\u7684\u3002Stpenbeck\u535a\u58eb\u7b49\u4eba\u6b64\u524d\u66fe\u5c06Paneth\u7ec6\u80de\u529f\u80fd\u969c\u788d\u4e0e\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u6307\u793aIBD\u7684\u80a0\u9053\u53d8\u5316\u4ee5\u53ca\u4e16\u754c\u5404\u5730\u591a\u4e2a\u961f\u5217\u7684\u514b\u7f57\u6069\u75c5\u60a3\u8005\u7684\u4e00\u4e2a\u5b50\u96c6\u8054\u7cfb\u5728\u4e00\u8d77\u3002 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